1,3-aminoalcohols

ABSTRACT

NOVEL 1,3-AMINOALCOHOL OF THE FORMULA   R&#39;&#39;,R&#34;,R&#34;&#39;&#39;;(-CH(-N&lt;(-Z-))-CH2-(CH2)N-CH2-)&gt;CH-CH(-OH)-)   BENZENE   WHEREIN N HAS THE VALUE OF 1 TO 4, INCLUSIVE, WHEREIN   -N&lt;(-Z-)   IS PYRROLIDINO, WHEREIN R&#39;&#39;, R&#34;, AND R&#39;&#39;&#39;&#39;&#39;&#39; ARE HYDROGEN, HALOGEN, ALKYL OR 1 TO 6 CARBON ATOMS, INCLUSIVE, AND ALKOXY OF 1 TO 6 CARBON ATOMS, INCLUSIVE, OR CF3, ARE PREPARED. THE NEW COMPOUNDS OF FORMULA IV PER SE AS WELL AS IN THE FORM OF ACID ADDITION SALTS HAVE DIURETIC ACTIVITY AND SOME OF THEM HAVE ANTI-HYPERGLYCEMIC ACTIVITY. COMPOUNDS OF FORMULA IV ARE THUS USEFUL TO PROVIDE DIURESIS IN MAMMALS ARE ARE ALSO USEFUL AS ORAL ANTIDIABETIC AGENTS.

United States Patent Office Patented Dec. 5, 1972 ABSTRACT OF THE DISCLOSURE Novel 1,3-aminoalchol of the formula wherein n has the value of 1 to 4, inclusive, wherein CROSS-REFERENCES TO RELATED APPLICATIONS This application is a division of application Ser. No. 556,892 filed June 13, 1966, by Jacob Szmuszkovicz, now allowed as US. Pat. No. 3,558,599, and a division of divisional application Ser. No. 786,395, filed December 23, 1968, both by Jacob Szmuszkovicz now US. Pat. No. 3,577,415.

This invention relates to new organic compounds and is particularly concerned with new 1,3-aminoalcohols, the intermediates thereof, the ethers, Noxides, acid addition salts and quaternary ammonium salts thereof as well as the process of production therefor.

The novel compounds and the basic process of invention can be illustratively represented by the following sequence of formulae:

N a. z IVb wherein n has the value of 1 to 4, inclusive, wherein III represents pyrrolidino wherein R is an alkyl containing from 1 to 6 carbon atoms, inclusive, wherein R, R, R' are selected from the group of substituents consisting of hydrogen, halogen, alkyl and alkoxy containing from 1 to 6 carbon atoms, inclusive, and -CF and wherein Ac is the acyl radical of a hydrocarbon carboxylic acid containing from 2 to 12 carbon atoms, inclusive.

The invention further includes the compounds of Formulae IV, IVa and Nb when in the form of the N-oxides, acid addition salts and quaternary alkyl ammonium halides in which the alkyl group has from 1 to 12 carbon atoms, inclusive, and the halogen can be chlorine, bromine and iodine. Also the acid addition salts of the compounds of Formula III are embraced by this invention.

Examples of the cycloalkyl radical illustratively represented by the formula l are cyclopentyl, cyclohexyl, cycloheptyl and cyclooctyl.

Examples of the heterocyclic amino radical m -N z \J having from 5 to 10 nuclear atoms, include: pyrrolidino, Z-methylpyrrolidino, Z-ethylpyrrolidino, 2,2-dimethylpyrrolidino, 3,4-dimethylpyrrolidino, -2-isopropylpyrrolidino, 2-sec.butylpyrrolidino, and like alkylpyrrolidino groups, morpholino, Z-ethylmorpholino, 2-ethyl 5 methylmorpholino, 3,3-dimethylmorpholino, thiamorpholino, 3- methylthiamorpholino, 2,3,6 trimethylt-hiamorpholino, 4 methylpiperazino, 4 butylpiperazino, piperidino, 2- methylpiperidino, 3-methylpiperidino, 4-methylpiperidino, 4-propylpiperidino, 2-propylpiperidino, 4-isopropylpiperidino, and like alkylpiperidino groups, hexamethyleneimino, 2-methylhexamethyleneimino, 3,6-dimethylhexamethyleneirnino, homomorpholino, 1,2,3,4 tetrahydroquinolyl, heptamethyleneimino, octamethyleneimino, 3- azabicyclo [3 .2.2]nonan-3-yl, 2-azabicyclo [2.2.2] octan-Z- yl, and the like.

Illustrative examples of alkyl groups having from 1 to 6 carbon atoms are methyl, ethyl, propyl, isopropyl, butyl, isobutyl, tertiary butyl, pentyl, Z-methylbutyl, neopentyl, hexyl, Z-methylpentyl, 3-methylpentyl and the like. Alkyl groups for the quaternary ammonium halide salts include, in addition to the preceding alkyl groups, others such as heptyl, octyl, nonyl, decyl undecyl, dodecyl and the like. The halogen moiety in such salts includes iodine, bromine and chlorine.

Illustrative examples of the acyl groups Ac of hydrocarbon carboxylic acids are particularly the acyl groups of alkanoic acids of 2 to 12 carbon atoms, e.g., acetyl, propionyl, butyryl, isobutyryl, valeryl, isovaleryl, hexanoyl, octanoyl, decanoyl, B-cyclopentylpropionyl, lauroyl; of benzoic and aralkanoic acids, e.g., benzoyl, phenylacetyl, 3-phenylpropionyl, toluoyl, ethylbenzoyl, propylbenzoyl; of alkenoic acids, e.g., acryloyl, crotonoyl,

chrysanthemummonocarbonyl, cinnamoyl, hexenoyl; of alkynoic acids, e.g., propioloyl, 2- and 3-butynoyl and the like.

Under halogen substitutents for R, R or R is understood fluorine, chlorine, bromine and iodine.

The novel compounds III, IV, IVa and IVb exist in different steroisomeric forms such as geometric and optically active forms (e.g., compounds of Formula III have at least two asymmetric carbon atoms, while the final products, IV, IVa and IVb, have at least three asymmetric carbon atoms) as well as in racemic mixtures. These optically active forms and racemic mixtures and geometric isomers are also encompassed by this invention.

The process of the present invention comprises: heating a diketo compound of Formula I in which one of the radicals on the central carbonyl group is a 2-oxocycloalkyl group having from 5 to 8 carbon atoms, inclusive, and the other group is substituted or unsubstituted phenyl, with a heterocyclic amine having from 5 to 10 nuclear atoms, inclusive, in the presence of an acidic catalyst, e.g., p-toluenesulfonic acid, to give the unsaturated keto compound of Formula II; hydrogenating the thus-obtained compound II in the presence of a hydrogenation catalyst, preferably a noble metal catalyst such as platinum oxide, rhodium, palladium or the like to add step-Wise one and thereupon two molar equivalents of hydrogen, thus yielding respectively (with 1 molar equivalent of hydrogen) the keto compound III and (with 2 molar equivalents of hydrogen) the alcohol IV. The thus-obtained 1,3-amino alcohols IV can be converted to alcohol derivatives such as ethers (IVa) with an alkyl halide (1 to 6 carbon atoms) in the presence of a base, or with a lower alkanol (1 to 6 carbon atoms) in the presence of anhydrous hydrogen chloride, and to esters (IVb) with an acid anhydride or acid halide in a suitable organic solvent.

The amino function in Formulae IV, Na and IVb compounds furthermore permits the transformation of these compounds, by neutralization with inorganic and organic acids, into acid addition salts such as the hydrochloride, hydrobromide, hydroiodide, sulfate, phosphate, perchlorate, pamoate, cyclohexanesulfamate, methanesulfonate, ethanesulfonate, p-toluenesulfonate, benzenesulfonate, tartrate, citrate, lactate, and the like. By treatment of the compounds of Formulae IV, IVa and IVb with peracids such as m-chloroperbenzoic acid, peracetic acid, perbenzoic acid, perphthalic acid, and the like, the corresponding N-oxide derivatives are obtained. By treatment of the compounds of Formulae IV, IVa and IV'b with alkyl halides, the corresponding quaternary ammonium halide halts are obtained.

The compounds of Formulate IV, IVa and IVb, including the acid addition salts, the N-oxides, and the alkyl quaternary ammonium halides thereof, are com pounds of significant diuretic activity. They may be administered to mammals and birds by both oral and parenteral routes in order to produce their pharmacological, that is, diuretic effects. For oral administration, the new compounds of Formulae IV, IVa and IVb, as well as the acid addition salts, the N-oxides and the quaternary ammonium halide salts, can be compounded into solid and liquid unit dosage forms such as tablets, capsules, powders, granules, syrups, elixirs and the like, containing the appropriate amounts for treatment. For tablets, common pharmaceutically acceptable carriers are used such as starch, lactose, kaolin, dicalcium phosphate and the like. The compounds IV, IVa and IVb can also be given as powders, particularly in gelatin capsules with or without carriers such as methylcellulose, magnesium stearate, calcium stearate, talc and the like. For fluid preparations, these compounds may be dissolved or sus- 4 pended in aqueous alcoholic vehicles with or without buffering agents and flavoring mixtures.

The thus-obtained pharmaceutical formulations are administered to edematous animals for the treatment of conditions associated with excess electrolyte retention and excess fluid retention. For example, the compositions are useful in treating the following conditions: edema associated with hepatic disease, edema and toxemia of pregnacy, hypertensive vascular disease, premenstrual fluid retention and congestive heart failure. Dosages between 0.5 and 30 mg./kg. of body weight are suitable to produce significantly increased diuresis. For example, the ether cis-1-[2 (a,p-dimethoxybenzyl)cycyohexyl] piperidine of melting point 8385 C. produced at 5 mg. dosage level per kg. of body weight of rats a 73% increase in diuresis, as determined by the procedure of Lipschitz et al., J. Pharmacol. Exp. Therap. 79, 97, 1943.

The compounds of Examples 38, 39, 48, 54, 55, 97, 99, and 136A have demonstrated significant antihyperglycemic acitivity in rats. They are useful as oral antidiabetic agents.

As noted above, the new compounds of Formulae IV, IVa and IVb can be used in the form of their acid addition salts with inorganic or organic acids, for example, hydrochlorides, lactates, sulfates, tartrates, hydroiodides, hydrobromides, and the like. Moreover, the fiuosilicates of these compounds are useful moth-proofing agents according to U.S. Pats. 1,915,334 and 2,075,359. The thiocyanic acid addition salts of the same compounds can be condensed with formaldehyde to form resinous polymers which according to US. Pats. 2,425,- 320 and 2,606,155 are useful as pickling inhibitors. The trichloroacetic acid addition salts of the compounds of the same Formulae IV, IVa and IVb are useful as herbicides, for example, against Johnson grass, yellow foxtail, green foxtail, Bermuda grass and quack grass.

The alkyl quaternary ammonium halides of the compounds of Formulae IV, IVa and IVb, such as tit-(3,4,5- trimethoxyphenyl)-2- (hexahydro l-methyll-azepinium) cyclohexanemethanol iodide ('Example 142), possess high wetting power and electroconductivity and are thus suitable to prepare electrocardiographic jellies.

A suitable composition of an electrocardiographic jelly thus prepared comprises:

Parts Glycerol 5 Starch 10 Quaternary ammonium salt 60 Water 100 The jelly is prepared by mixing the starch, glycerol and water and then adding the quaternary ammonium salt. The mixture is then allowed to stand for at least two days with occasional agitation to allow the formation of a gel.

The starting materials of Formula I are known in part from the art, e.g., Campbell et al., J. Am. Chem. Soc. 82, 2389, (1960); Linn et al., J. Am. Chem. Soc. 78, 6066 (1956); Eistert et al., Ann. 650, 133 (1961). An elegant method by which the 1,3-diones of the type of Formula I are synthesized consists of the reaction of a selected cycloalkanone with pyrrolidine or piperidine to give the corresponding enamine and to react the enamine with a selected substituted or unsubstituted benzoyl chloride [Campbell et al., J. Org. Chem. 28, 379 (1963)]. This particular method is shown repeatedly in the examples in order to synthesize hitherto unknown 1,3-diones of the type of Formula I.

In carrying out the process of the present invention a 1,3-diketo compound (1) is reacted with a heterocyclic amine in the presence of an acid catalyst and preferably under conditions in which the water produced in the condensation process is separated from the reaction mixture such as by employing an azeotropic separator together with the reflux condenser. As solvent, essentially water-free organic solvents are used such as benzene,

toluene, xylene or the like. The heterocyclic amines used include particularly pyrrolidine, Z-methylpyrrolidine, 2- ethylpyrrolidine, 2,2 dimethylpyrrolidine, 3,4 dimethylpyrrolidine, Z-isopropylpyrrolidine, 2-sec.butylpyrrolidine and other like alkylpyrrolidines; morpholine, 2-ethylmorpholine, 2 ethyl-S-methylmorpholine, 3,3 dimethylmorpholine, thiamorpholine, 3 methylthiamorpholine, 2,3,6-trimethylthiamorpholine and other like alkylmorpholines and alkylthiamorpholines; 4-methylpiperazine, 4-butylpiperazine and other like alkylpiperazines; piperidine, Z-methylpiperidine, 3-methylpiperidine, 4-methylpiperidine, 4-propylpiperidine, 2-propylpiperidine, 4-isopropylpiperidine and other like alkylpiperidines; hexamethyleneimine, 2 methylhexamethyleneimine, 3,6 dimethylhexamethyleneimine and other like alkylhexamethyleneimines; homomorpholine, 1,2,3,4 tetrahydroquinoline, heptamethyleneimine, octamethyleneimine, 3-azabicyclo[3.2.2]nonane, 2-azabicyclo[2.2.2]octane, and the like.

The reaction is generally carried out at temperatures between 50-150 C. but lower or higher temperatures are operative. Preferably, the reaction is carried out at the reflux temperature of the reaction mixture. The time for completion of the reaction is between 1 hour and 48 hours, but if low temperatures are used, longer reaction times are necessary. When the reaction is terminated, the product is isolated in conventional manner such as evaporating the reaction mixture to dryness.

The keto product of Formula II is then hydrogenated in the presence of a catalyst, preferably platinum oxide, at a hydrogen pressure between 40 and 60 pounds per square inch. Larger or smaller pressures can be used, but pressures between 50-55 pounds at the beginning of the reaction are found to be most convenient, The reaction can be followed by the hydrogen absorption and can be allowed to go to completion, that is, to the point of addition of 2 molar equivalents of hydrogen to give the alcohol of Formula IV, or alternatively may be interrupted after the addition of 1 molar equivalent of hydrogen to give the keto compound of Formula III. In cases where the addition of hydrogen is slow, additional amounts of catalyst may be added after an interval of several hours. Other catalysts that can be used in this reaction are palladium and rhodium, and these catalysts can be used with catalyst carriers such as charcoal, alumina and the like. After the hydrogenation is completed, the product is isolated by filtering the mixture to remove the catalyst and evaporating the solvent to obtain either the keto compound of Formula III or the alcohol of Formula IV. The thus-isolated products are purified by conventional means such as by crystallization and recrystallization, chromatography, or the like. If desired, the keto product of Formula III can be hydrogenated again to give the alcohol of Formula IV.

The conversion of the alcohol of Formula IV to an ether of Formula IVa is usually achieved by two methods: (l) reacting the alcohol of Formula IV in liquid ammonia containing sodium amide or potassium amide at low temperature with the selected alkyl halide, or (2) reacting the alcohol of Formula IV with a lower alkanol in the presence of hydrogen chloride. The starting temperature of the first method is usually the temperature of a Dry Ice-acetone bath, that is, approximately 70 C. and is completed at about room temperature. In the preferred embodiment of this invention, the selected alcohol (IV), is dissolved in ether and is added to liquid ammonia containing sodium amide under continuous stirring. When this mixture reaches the Dry Ice-acetone bath temperature, a solution of the alkyl halide, preferably an alkyl iodide, is added over a few minutes time to allow cooling. When the calculated amount of alkyl halide is consumed, the reaction mixture in the flask is removed from the Dry Ice-acetone bath and allowed to Warm to room temperature under continuous stirring. Instead of sodium amide, other strong basic compounds can be used such as potassium amide, lithium amide, and the like. Instead of liquid ammonia and alkali metal amides, other reaction systems can be used, e.g., butyl lithium in the presence of tetrahydrofuran and a temperature range of about 70 to 25 C. After the reaction is terminated, the ether thus produced (IVa) is isolated by conventional procedures such as extraction, evaporation of solvents, formation of amine addition salts such as the hydrochloride, and using the differential water solubility of the hydrochloride and the like. For purification, recrystallization and chromatography are usually employed.

In the second method, the alcohol IV is stirred with a solution of hydrogen chloride gas in a lower alkanol, e.g., methanol, ethanol, propanol, l-butanol, Z-butanol and the like, usually at room temperature. Lower or higher temperatures are operative, however. The product is obtained as a hydrochloride of the amino ether. The free base is obtained by treating the hydrochloride with a base, e.g., 20% aqueous sodium hydroxide, extracting the free base with a water-immiscible solvent, e.g., ether, methylene chloride, chloroform and the like and evaporating the solvent.

Esters (IVb) of the alcohol of Formula IV are usually obtained in conventional manner, that is, treatment of the alcohol with an acid anhydride or acid halide, preferably in solution at room temperature. The solvents used in this reaction are methylene chloride, tetrahydrofuran, pyridine and the like. The anhydrides used in this reaction are usually of hydrocarbon carboxylic acids, e.g., of alkanoic acids such as acetic, propionic, butyric, isobutyric, valeric, hexanoic, heptanoic, octanoic acids and the like; of benzoic and aralkanoic acids such as benzoic acid, salicyclic acid, toluic acid, phenylacetic acid, 3-phenylpropionic acid and the like; of cycloalk'anoic acids, e.g., of cyclohexanecarboxylic acid and the like. The acid halides used in this reaction can be of alkanoic acids, particularly higher alkanoic acids having from 6 to 12 carbon atoms, such as hexanoyl chloride, heptanoyl chloride, octanoyl chloride, decanoyl chloride, undecanoyl chloride, lauroyl chloride or the acid bromides thereof, but the chlorides and bromides of lower alkanoic acids are also useful. The invention also encompasses the use of the anhydrides and acid chlorides and bromides of unsaturated acids such as cinnamic acid, acrylic acid, crotonic acid, propiolic acid, 2- butynoic acid, chrysanthemummonocarboxylic acid and the like. After termination of the reaction, the product is isolated by conventional procedures such as extraction, chromatography, crystallization and the like.

Acid addition salts of the amino alcohols (IV), amino ethers (IVa) and amino esters (IVb) are synthesized in the usual manner, that is, by directly reacting the acid with the free amine, preferably in an aqueous or anhydrous solvent such as water, ether, methanol, ethanol, ethyl acetate or the like. Evaporation of the solvent provides the desired acid addition salt.

N-oxides of the compounds of Formulae IV, We. and Nb are obtained by reacting the compound at a temperature between 0-30 0., preferably at the start of the reaction at a temperature between 010 C., with a peracid such as peracetic, perpropionic, perbenzoic, perphthalic, m-chloroperbenzoic or other organic peracids in a Solvent such as methanol, ethanol, ether or the like. Evaporation of the solvent provides the desired N-oxide of the products of Formulae IV, IVa and Nb.

The alkyl quaternary ammonium halides of products of Formula IV, IVa and IVb are produced by conventional methods such as heating to reflux a solution of the selected compound IV, IVa or IVb in the presence of methanol, ethanol, acetonitrile or the like with a selected alkyl halide such as an iodide or bromide or, less desirably, a chloride of methyl, ethyl, propyl, butyl, isobutyl, isopropyl, pentyl, hexyl, heptyl, octyl, decyl, undecyl, dodecyl or isomers of these alkyl compounds. After the reac- 7 tion is terminated the reaction mixture is evaporated to dryness to give the product which can be purified by recrystallization from organic solvents such as methanol, ethanol, ether, Skellysolve B hexanes, mixtures thereof and the like.

It is obvious from the configuration of products III, IV, IVa and IVb that these products can exist in more than one isomeric structure, since the compounds of Formula III have at least two asymmetric centers and those of Formula IV, Na and IVb have at least three asymmetric centers, as noted above. It will be seen from the Examples that many of the reactions are either stereo-specific giving only one single product (racemic) or are stereo-selective, that is, giving one major component with smaller amounts of other components. Thus, the hydrogenation of the compound II to the ketone III with platinum oxide appears to give only one single form of the cis-ketone, Heating the thus-obtained cis-ketone with a base, for example, refluxing it with piperidine, produces a single trans-ketone (III), which according to thermodynamic principles of stability has the substituents on the cycloalkane moiety in the equatorial position.

Further hydrogenation of a cis-ketone of Formula III with platinum oxide as catalyst produces one single cisalcohol form (racemate A). Heating this cis-alcohol of Formula IV with trifluoroacetic acid produces another Formula IV cis-alcohol (racemate B).

Further hydrogenation of a trans-ketone of Formula III with platinum oxide as catalyst produces one single Formula IV trans-alcohol (racemate C) which can be converted to the other Formula IV trans-alcohol (racemate D) with trifluoroacetic acid. Reduction of a trans-ketone of Formula III with lithium aluminum hydride produces the two above-mentioned trans-alcohols of Formula IV. The racemates can be resolved by standard methods. The subsequent examples further illustrate the stereo-isomeric considerations.

The following examples are illustrative of the process and the products of the present invention, but are not to be construed as limiting.

EXAMPLE 1 2- 3 ,4,5-trimethoxybenzoyl cyclohexanone A mixture of 147 g. (1.5 moles) of cyclohexanone and 213.3 g. (3 moles) of pyrrolidine was refluxed in 2250 ml. of benzene in a flask equipped with an azeotropic separator. After the water formed during the reaction was collected, the solution was evaporated to dryness in vacuo and the resulting crude oil, consisting of l-pyrrolidino-lcyclohexene, was used directly for the next step.

A solution of 3,4,5-trimethoxybenzoyl chloride (138.3 g.; 0.6 mole) in 240 ml. of chloroform was added during a period of 2 hours to a solution of the crude l-pyrrolidino-l-cyclohexene in 630 ml. of chloroform, under a nitrogen atomsphere, with continuous stirring while keeping the temperature between 5 to C. After the solution was stirred overnight (about 18 hours) at room temperature (about 22 to 25 C.), there was added 900 ml. of 10% aqueous hydrochloric acid, and the resulting mix ture was stirred at room temperature for 2 hours. The aqueous layer was extracted with two 150-ml. portions of chloroform, and the chloroform extracts were combined with the chloroform layer above. The combined extracts were washed with water, saturated aqueous sodium bicarbonate solution, water and saturated salt solution. The thus-obtained chloroform solution was dried by passing it through anhydrous sodium sulfate and the dry solution was evaporated to give a residue which was crystallized from methanol to yield 100 g. of long, colorless needles of 2-(3,4,5-trimethoxybenzoyl)cyclohexanone of melting point 141142 C.

Analysis-Calm. for C H O (percent): C, 65.74, H, 6.90. Found (percent): C, 65.48; H, 6.84.

EXAMPLE 2 2- 3 ,4, 5 -trimethoxybenzoyl cyclop entanone A mixture of 126 g. (1.5 moles) of cyclopentanone and 213.3 g. (3 moles) of pyrrolidine was refluxed in 2250 ml. of benzene in a flask equipped with an azeotropic separator. After the calculated amount of water, produced during the condensation, had been collected, the reaction mixture was evaporated to give as an oil l-pyrrolidino-l-cyclopentene.

A solution of 3,4,5-trimethoxybenzoyl chloride (138.3 g.; 0.6 mole) in chloroform was added to a chloroform solution of the oily l-pyrrolidino-l-cyclopentene over a period of 1 hour. The reaction mixture was thereupon worked up as in Example 1 to give a brown oil weighing 190 g. This oil was dissolved in 500 ml. of ethanol and the ethanol solution was added to a solution of 172 g. of cupric acetate monohydrate in 2600 m1. of water. The mixture was stirred for /2 hour, cooled. and filtered, providing a crude copper complex of 2-(3,4,5-trimethoxybenzoyl) cyclopentanone. This product was crystallized from methylene chloride to give g. of the pure copper complex melting at 206-208 C.

Analysis.-Calcd. for C H CuO (percent): C, 58.29; H, 5.54; Cu, 10.28. Found (percent): C, 58.58; H, 5.81; Cu, 9.49.

The thus-obtained copper complex (70 g.) was dissolved in 350 ml. of chloroform and decomposed with 670 ml. of 10% aqueous hydrochloric acid to give 60 g. (yield 36%) of 2-(3,4,5-trimethoxybenzoyl)cyclopentanone having a melting point of 8186 C. A sample of this material was recrystallized from Skellysolve B hexanes to give 2-(3,4,5-trimethoxybenzoyl)cyclopentanone of melting point 9295 C.

Analysis.-Calcd. for C H O (percent): C, 64.73; H, 6.52. Found (percent): C, 64.95; H, 6.52.

In a run twice the size of the above synthesis, a yield of 47% was obtained.

EXAMPLE 3 2- 3 ,4,5-trimethoxybenzoyl cycloheptanone A mixture of 500 g. of cycloheptanone (4.5 moles), 7-85 g. of morpholine (9 moles), 900 ml. of toluene and 5 g. of p-toluenesulfonic acid was refluxed for 23 hours, collecting the water produced in the reaction with an azeotropic separator. Ninety-eight ml. of a lower phase was collected and discarded. The remaining mixture was then evaporated in vacuo to give an oil which was distilled. The fraction boiling between 119-125 C. consisting essentially of 262.7 g. of l-morpholino-l-cycloheptene (32% yield).

In the manner given in Example 1, 3,4,5-trimethoxybenzoyl chloride (92.5 g.; 0.4 mole) was reacted with 181.37 g. (1 mole) of l-morpholino-l-cycloheptene. The crude product was crystallized from 500 ml. of methanol and gave a first crop of 26 g. of 2-(3,4,5-trimethoxybenzoyl)cycloheptanone of melting point 99-100 C. After two more recrystallizations from methanol, the product had a melting point of 107-108" C.

Analysis.-Calcd. for C11H2205 (percent): C, 66.65; H, 7.24. Found (percent): C, 66.16; H, 7.48.

From the above methanolic filtrate another 48.3 g. of 2-(3,4,5-trimethoxybenzoyl)cycloheptanone was obtained as a second crop. The total yield was 61%.

EXAMPLE 4 2- (p-rnethoxybtinzoyl) cyclohexanone A solution of 167 g. (0.98 mole) of p-anisoyl chloride in 480 ml. of chloroform was added during a period of 1.5 hours to a solution of 371.7 g. (2.46 moles) of distilled 1-pyrrolidino-l-cyclohexene in 1260 ml. of chloroform. The temperature was kept between 5-10 C. by cooling with ice. After stirring for a period of about 20 hours at room temperature, the mixture was decomposed by addition of 1800 m1. of 10% aqueous hydrochloric acid over a period of 20 minutes. The mixture was then stirred for 2 hours, allowed to settle, the organic layer was separated and the aqueous layer extracted twice with 250-ml. portions of chloroform. The original organic layer and the chloroform extracts were combined, washed with water, saturated salt solution, and then dried by passage through sodium sulfate and evaporated. The residue resulting from the above evaporation was a brown oil which was dissolved in 1 l. of ethanol and added to a solution of 344 g. of cupric acetate monohydrate in 5200 ml. of water, preheated to 65 C. The mixture was stirred for 0.5 hour, cooled to room temperature and filtered. The obtained precipitate was washed with water and then with ether. It was then dissolved in 800 ml. of chloroform and added to a solution of 300 ml. of concentrated hydrochloric acid in 1100 ml. of water. The mixture was stirred for 1 hour. The organic layer was separated, and the aqueous layer was extracted once with chloroform. The combined chloroform original layer and extract were washed with water, saturated salt solution, dried by passing through anhydrous sodium sulfate and evaporated, to give a solid which was crystallized from 7 l. of methanol, yielding 136.5 g. of Z-(p-methoxybenzoyl)cyclohexanone having a melting point of 115-128 C. A second crop of 26 g., melting point 116-127 C., was obtained from the mother liquor; the total yield was 71%. A recrystallized sample from methanol of 2-(pmethoxybenzoyl)cyclohexanone had a melting point of 117-122 C.

Analysis.-Calcd. for C H O (percent): C, 72.39; H, 6.94. Found (percent): C, 72.30; H, 7.05.

EXAMPLE 5 2- (p-methoxyb enzoyl) cyclop entanone In the manner given in Example 2, 204 g. (1.2 moles) of p-anisoyl chloride was reacted with l-pyrrolidino-lcyclopentene prepared from 252 g. (3 moles) of cyclopentanone. The crude product was converted to the copper complex as in Example 4, the complex being crystallized from chloroform-ether to give 80 g. of copper complex of 2- (p-methoxybenzoyl)cyclopentanone with a melting point of 252 C. (dec.). The copper complex was decomposed with hydrochloric acid to give 67 g. of an oil which was crystallized from methanol to give 13.9 g. of 2-(p-methoxybenzoyl)cyclopentanone of melting point 82-83" C. The filtrate from the first crystallization was evaporated to dryness and the residue crystallized from ether-Skellysolve B hexanes to give 30.1 g. of a second crop of 2-(p-methoxybenzoyl)cyclopentanone of melting point 76-77 C. (total yield 17%). Two recrystallizations from methanol gave 2-(p-methoxybenzoyDcyclopentanone having a melting point of 83-87 C.

Analysis.Calcd. for C H O (percent): C, 71.54; H, 6.47. Found (percent): C, 71.83; H, 6.48.

EXAMPLE 6 2- (p-ethoxybenzoyl) cyclohexanone In the manner given in Example 2, l-piperidino-lcyclohexene was reacted with p-ethoxybenzoyl chloride in chloroform solution to give, after the copper complex purification procedure (Example 2), 2-(p-ethoxybenzoyl) cyclohexanone.

EXAMPLE 7 2- (p-benzyloxybenzoyl cyclohexanone In the manner given in Example 2, l-pyrrolidino-lcyclohexene was reacted with p-benzyloxybenzoyl chloride in chloroform solution to give, after the copper complex purification procedure (Example 2), 2-(p-benzyloxybenzoy1)cyclohexanone of melting point 111-111.S C.

EXAMPLE 8 2- [p- (Z-hydroxyethoxy) benzoyl] cyclohexanone In the manner given in Example 2, l-piperidino-l-cyclohexene was reacted with p-(2-acetoxyethoxy)benzoyl chloride in chloroform solution to give, after the copper complex purification procedure (Example 2), 2r[p-(2- acetoxyethoxy)benzoyl]cyclohexanone. The 2 [p-(2- acetoxyethoxy)benzoyl]cyclohexanone was subjected to alkaline hydrolysis in conventional manner, neutralized with acid and 2-[p-(2-hydroxyethoxy)benzoyl]cyclohexanone recovered by extraction.

EXAMPLE 9 2- o-methoxyb enzoyl cyclohexanone In the manner given in Example 2, l-piperidino-l-cyclohexene was reacted with o-methoxybenzoyl chloride in chloroform solution to give, after the copper complex purification procedure (Example 2), 2-(o-methoxybenzoyl)cyclohexanone of melting point 6S-68 C.

EXAMPLE 1O 2- (o-hydroxybenzoyl) cyclohexanone In the manner given in Example 2, l-piperidino-lcyclohexene was reacted with o-acetoxybenzoyl chloride in chloroform solution to give, after the copper complex purification procedure (Example 2), 2-(o-acetoxybenzoyl) cyclohexanone. The thus-obtained 2-(o-acetoxybenzoyl) cyclohexanone was subjected to alkaline hydrolysis, the mixture acidified and the 2-(o-hydroxybenzoyl)cyclohexanone recovered by extraction.

EXAMPLE 11 2-(2-methoxy-4-methylbenzoyl)cyclohexanone In the manner given in Example 2, l-piperidino-l-cyclohexene was reacted with 2-methoxy-4-methylbenzoyl chloride in chloroform solution to give, after the copper complex purification procedure (Example 2), 2-(2-methoxy- 4-methylbenzoyl cyclohexanone.

EXAMPLE 12 2- p-methoxybenzoyl -4,4-dimethylcyclohexanone In the manner given in Example 2, 1-piperidino-4,4- dimethyl-l-cyclohexene was reacted with p-methoxybenzoyl chloride in chloroform solution to give, after the copper complex purification procedure (Example 2), 2-(p-methoxybenzoyl)-4,4-dimethylcyclohexanone.

EXAMPLE 13 2- 3 ,5 -dimethyl-4-methoxybenzoyl) cyclohexanone In the manner given in Example 2, l-pyrrolidino-lcyclohexene was reacted with 3,5-dimethyl-4-methoxybenzoyl chloride in chloroform solution to give, after the copper complex purification procedure (Example 2), 2-

(3,5-dimethyl-4-methoxybenzoyl)cyclohexanone of melting point l25126 C.

EXAMPLE 14 2; [p-methylcarbamoyloxy benzoyl] cyclohexanone In the manner given in Example 2, l-piperidino-lcyclohexene was reacted with p-methylcarbamoyloxybenzoyl chloride in chloroform solution to give, after the copper complex purification procedure (Example 2), 2 [p-(methylcarbamoyloxy)benzoyl1cyclohexanone.

EXAMPLE 15 L- (3 ,4-methylenedioxybenzoyl) cyclohexanone In the manner given in Example 2, l-piperidino-lcyclohexene was reacted with 3,4-methylenedioxybenzoyl chloride in chloroform solution to give, after the copper complex purification procedure (Example 2), 243,4- methylenedioxybenzoyl) cyclohexanone.

EXAMPLE l6 2- (p-chlorobenzoyl) cyclohexanone In the manner given in Example 2, l-piperidiuo-l-cyclohexene was reacted with p-trifluoromethylbenzoyl chloride in chloroform solution to give, after the copper complex purification procedure (Example 2), 2- (p-trifluoromethylb enzoyl) cyclohexanone.

EXAMPLE 17 2- p-chlorobenzoyl cyclohexanone In the manner given in Example 2, l-piperidino-lcyclohexene was reacted with p-chlorobenzoyl chloride in chloroform solution to give, after the copper complex purification procedure (Example 2), 2-(p-chlorobenzoyl) cyclohexanone.

EXAMPLE 18 2- p-hydroxybenzoyl cyclohexanone In the manner given in Example 2, l-piperidino-l-cyclohexene was reacted with p-acetoxy'benzoyl chloride in chloroform solution to give, after the copper complex purification procedure (Example 2), 2-(p-acetoxybenzoyl)cyclohexanone. The thus-obtained 2-(p-acetoxybenzoyl)cyclohexanone was subjected to alkaline hydrolysis, the mixture acidified and the 2-(p-hydroxybenzoyl)cyclohexanone recovered by extraction.

EXAMPLE 19 2-(omethylbenzoyl)cyclohexanone In the manner given in Example 2, l-piperidino-lcyclohexene was reacted with o-methylbenzoyl chloride in chloroform solution to give, after the copper complex purification procedure Example 2), 2-(o-methylbenzoyl) cyclohexanone.

EXAMPLE 20 2- (p-methylbenzoyl) cyclohexanone In the manner given in Example 2, l-pyrrolidino-lcyclohexene was reacted with p-methylbenzoyl chloride in chloroform solution to give, after the copper complex purification procedure (Example 2), 2-(p-methylbenzoyl)cyclohexanone of melting point 108-l C.

EXAMPLE 21 2- (2,4-dimethylbenzoyl) cyclohexanone In the manner given in Example 2, l-pyrrolidino-lcyclohexene was reacted with 2,4-dimethylbenzoyl chloride in chloroform solution to give, after the copper complex purification procedure (Example 2), 2-(2,4-dimethylbenzoyl)cyclohexanone of melting point 51-52.5 C.

EXAMPLE 22 2- (2-methoxy-4-methylbenzoyl cyclohexanone In the manner given in Example 2, 1-piperidino-lcyclohexene was reacted with 2-methoxy-4-methylbenzoyl chloride in chloroform solution to give, after the copper complex purification procedure (Example 2), 2(2- methoxy-4-methylbenzoyl) cyclohexanone.

EXAMPLE 23 2- (Z-hydroxy-S-chlorobenzoyl cyclohexanone In the manner given in Example 2, l-piperidino-lcyclohexene was reacted with 2-acetoxy-S-chlorobenzoyl chloride in chloroform solution to give, after the copper complex purification procedure (Example 2), 2-(2- acetoxy-S-chlorobenzoyl) cyclohexanone. The thus-obtained 2-(2-acetoxy-S-chlorobenzoyl)cyclohexanone was subjected to alkaline hydrolysis, the mixture acidified and the 2-(2-hydroxy-5-chlorobenzoy1)cyclohexanone recovered by extraction.

EXAMPLE 24 2- (p-allyloxybenzoyl) cyclohexanone In the manner given in Example 2, l-piperidino-lcyclohexene was reacted with p-allyloxybenzoyl chloride in chloroform solution to give after the copper complex purification procedure (Example 2), 2-(p-allyloxybenzoyl)cyclohexanone.

EXAMPLE 25 2- [p- (carboxymethoxy) benzoyl cyclohexanone In the manner given in Example 2, l-piperidino-l-cyclohexene was reacted with p-(carboxymethoxy)benzoyl chloride in chloroform solution to give, after the copper complex purification procedure (Example 2), 2-[p-(carboxymethoxy) benzoyl] cyclohexanone.

EXAMPLE 26 2- (p-benzyloxybenzoyl cycloheptanone In the manner given in Example 2, l-pyrrolidino-lcycloheptene was reacted with p-benzyloxybenzoyl chloride in chloroform solution to give after the copper complex purification procedure (Example 2), 2-(p-benzloxybenzoyl) cycloheptanone.

EXAMPLE 27 2- (p-ethoxybenzoyl) cyclooctanone In the manner given in Example 2, l-morpholino-lcyclooctene was reached with p-ethoxybenzoyl chloride in chloroform solution to give, after the copper complex purification procedure (Example 2), Z-(p-ethoxybenzoyl) cyclooctanone.

EXAMPLE 28 2- (2,3 ,4-trimethoxybenzoyl) cyclooctanone In the manner given in Example 2, 1piperidino-1-cyclooctene was reacted with 2,3,4-trimethoxybenzoyl chloride in chloroform solution to give, after the copper complex purification procedure (Example 2), 2-(2,3,4-trimethoxybenzoyl) cyclooctanone.

EXAMPLE 29 2- (p-bromobenzoyl) cyclooctanone In the manner given in Example 2, l-piperidino-l-cyclooctene was reacted with p-bromobenzoyl chloride in chloroform solution to give, after the copper complex purification procedure (Example 2), 2-(p-bromobenzoyl) cyclooctanone.

EXAMPLE 30 2- S-methylbenzoyl) cyclooctanone In the manner given in Example 2, l-piperidino-l-cyclooctene was reacted with 3-methylbenzoyl chloride in chloroform solution to give, after the copper complex purification procedure (Example 2), 2-(3-methylbenzoyl) cyclooctanone.

In the same manner given in the foregoing examples, other 2-benzoylcycloalkanones of Formula 1 (starting compounds) are prepared by reacting a l-cyclicamino-lcycloalkene, wherein the cycloalkene moiety has from 5 to 8 nuclear carbon atoms, inclusive, and the cyclicamino moiety has from 5 to 10 nuclear atoms, inclusive, with a selected benzoyl chloride. Representative starting materials, thus prepared include:

1 3 2- (2-propylbenzoyl) cycloheptanone; 2- (3-ethylbenzoyl cyclooctanone; 2- 2-methoxy-5-bromo cyclopentanone; 2-benzoylcyclooctanone; 2-benzoylcycloheptanone; and the like.

EXAMPLE 3 1 3,4,5-trimetho-xyphenyl 2-piperidino-l-cyclohexen-l-yl ketone A mixture consisting of 35 g. (0.12 mole) of 2-(3,4,5- trimethoxybenzoyl)cyclohexanone, 30.6 g. (0.36 mole) of piperidine, 960 ml. of toluene, and 0.8 g. of p-toluenesulfonic acid was refluxed for 23 hours under nitrogen using an azeotropic separator (during this time 1.8 ml. of water was collected). The mixture was thereupon evapmated to dryness to give partially crystalline 3,4,5-trimethoxyphenyl 2-piperidino-l-cyclohexen-l-yl ketone.

EXAMPLE 32 a-(3 ,4,5trimethoxyphenyl) -2-piperidinocyclohexanemethanol and its hydrochloride A solution of 3,4,5-trimethoxyphenyl 2-piperidino-1- cyclohexen-l-yl ketone [prepared from 35 g. of 2-(3,4,5- trimethoxybenzoyl)cyclohexanone and 30.6 g. of piperidine, as in Example 31] in 300 ml. of ethanol was hydrogenated in the presence of 1.2 g. of platinum oxide at an initial pressure of 50.1 pounds of hydrogen. Two molar equivalents of hydrogen were taken up during 3.5 hours. The mixture was filtered through a filter aid and evaporated to dryness. The oily residue was dissolved in 400 ml. of ether and 400 ml. of 10% aqueous hydrochloric acid was added, The thus-obtained reaction mixture was stirred for 0.5 hour. A suspension was obtained which was filtered, yielding an original filtrate and a solid which was washed with ether. The solid was twice recrystallized from methanol to give 14.7 g. of -(3,4,5-trimethoxyphenyl) 2 piperidinocyclohexanemethanol hydrochloride of melting point 265266 C. An analytical sample, prepared by additional recrystallization from methanol had a melting point of 266-267 C.

Ultraviolet: sh. 228 (8,100); sh. 232; r max. 269 (825); sh. 278 (612).

Analysis.-Calcd. for C H NO -HC1 (percent): C, 63.06; H, 8.57; Cl, 8.87; N, 3.50. Found (percent): C, 62.99; H, 8.24; Cl, 8.66; N, 3.46.

The above original filtrate was separated into layers, the aqueous layer was extracted with ether and then basified and extracted with methylene chloride. The extract was washed with water and saturated salt solution, then dried by pouring through anhydrous sodium sulfate and the water-free solution was evaporated to give 5.0 g. of an oil. The oil was converted to the hydrochloride with ethereal hydrogen chloride to give a second crop of 0.7 g. of a-(3,4,5 trimethoxyphenyl) 2 piperidinocyclohexanemethanol hydrochloride (total yield 3%; 15.4 g.).

The ether layer, after washing, drying and evaporation, gave 6.1 g. of an oil which was redissolved in ether and allowed to crystallize, yielding 0.5 g. of c (3,4,5 trimethoxyphenyl)-2-hydroxycyclohexanemethanol of melting point 130131 C. (after additional recrystallization from ether).

Analysis.-Calcd. for C H O (percent): C, 64.84; H, 8.16. Found (percent): C, 64.69; H, 8.29.

EXAMPLE 33 3,4,5-trimethoxyphenyl 2-morpholino-l-cyclohexen-l-yl ketone In the manner given in Example 31, 8.75 g. of 2-(3,4,5- trimethoxybenzoyl)cyclohexanone, 7.84 g. of morpholine, 240 ml. of benzene and 0.2 g. of p-toluenesulfonic acid was refluxed under nitrogen for a period of 23 hours whereby 0.49 ml. of water was collected. The solution was evaporated and the material worked up as in Example 14 31 to give 3,4,5-trimethoxyphenyl 2-morpholino-l-cyclohexen-l-yl ketone.

EXAMPLE 34 a- 3,4,5-trimethoxyphenyl -2-morpholinocyclohexanemethanol and its hydrochloride A solution of 3,4,5-trimethoxyphenyl Z-morpholino-lcyclohexene-l-yl ketone [produced as in Example 33 from 8.75 g. of 2-(3,4,5-trimethoxybenzoyl)cyclohexanone] in ml. of ethanol was hydrogenated in the presence of 0.3 g. of platinum oxide catalyst at an initial hydrogen pressure of 52.5 pounds. Two molar equivalents of hydrogen were taken up during a period of 6 hours. The mixture was filtered through diatomaceous earth (Filtercel) and evaporated to dryness. The resulting oil was dissolved in 100 ml. of 10% aqueous hydrochloric acid, 100 ml. of ether was added and the mixture was stirred for /2 hour. The aqueous layer was extracted twice with two 50-ml. portions of ether. The ether extracts were combined, washed with water, then with saturated salt solution, and finally dried by passage through anhydrous sodium sulfate. The thus-obtained solution was evaporated to give 2.3 g. of an oily material which after crystallization from ether gave 1 g. of 1-(3,4,5-trimethoxybenzoyl)-l-cyclohexene of melting point 73 74 C.

The above aqueous layer was cooled in ice, basified by adding sodium hydroxide solution and extracted with methylene chloride (three portions of 100 ml.). The extracts were combined, washed with water and saturated salt solution, and dried by passing through anhydrous sodium sulfate. The thus-obtained solution was concentrated to give 7.89 g. of an oily material which was converted to the hydrochloride by adding a solution of hydrogen chloride in ether. The solid thus obtained was recrystallized from methanol-ether to give 5 g. (42% yield) of a- (3,4,5 trimethoxyphenyl) 2 morpholinocyclohexanemethanol hydrochloride of melting point 205-206 C.

Ultraviolet: sh. 228 (8,150); sh. 236 (6,350); A max. 269 (788); sh. 278 (555).

Analysis.-Calcd. for C H NO -HCl (percent): C, 59.76; H, 8.03; Cl, 8.82; N, 3.49. Found (percent): C, 59.81; H, 8.52; Cl, 8.52; N, 3.57.

EXAMPLE 35 3,4,5-trimethoxypheny1 2-(4-methyl-1-piperazinyl)-1- cyclohexen-l-yl ketone A mixture of 8.75 g. (0.03 mole) of 2-(3,4,5-trimethoxybenzoyl)cyclohexanone, 9 g. (0.09 mole) of N-methylpiperazine, 240 ml. of toluene and 0.2 g. of p-toluenesulfonic acid was refluxed in a nitrogen atmosphere for a period of 7 hours. After 7 hours, 0.6 ml. of water had been collected in an azeotropic separator. The reaction mixture was thereupon evaporated to dryness to give 3, 4,5 trimethoxyphenyl 2-(4-methyl-l-piperazinyl)-l-cyclohexen l-yl ketone.

EXAMPLE 36 a-(3,4,5-trimethoxyphenyl)-2-(4-methyl-l-piperazinyl) cyclohexanemethanol dihydrochloride A solution of 3,4,5 trimethoxyphenyl 2-(4-methyl-1- piperazinyl)-1-cyclohexen-1-yl ketone, prepared from 8.75 g. of 2-(3,4,5 trimethoxybenzoyl)cyclohexanone as in Example 35, was dissolved in 100 ml. of methanol and then hydrogenated in the presence of 0.3 g. of platinum oxide at an initial pressure of 54 pounds. After 6.5 hours, the hydrogenation became sluggish, therefore, 0.03 mole of acetic acid and 0.3 g. of platinum oxide were added. After another period of 3 hours a total of 2 molar equivalents of hydrogen was absorbed. The mixture was filtered through diatomaceous earth (Filtercel) and evaporated to dryness. The resulting oil was dissolved in 100 ml. of 10% aqueous hydrochloric acid and 100 ml. of ether and the solution was stirred for 0.5 hour. The aqueous layer was extracted with three 50-ml. portions of methylene chloride. The extracts were discarded. The aqueous solution was then basified and extracted with four portions of 50 ml. each of methylene chloride. The methylene chloride extracts were combined, washed with water and with saturated salt solution, dried by passing through anhydrous sodium sulfate and evaporated to give 5.9 g. of oil. The oil was dissolved in ether and then acidified with 35 ml. of 2 N ethereal hydrogen chloride. The resulting solid was recrystallized from methanol, yielding 4.4 g. (31% yield) of u- (3 ,4,5-trimethoxyphenyl)-2-(4-methyl-1-piperazinyl)cyclohexanemethanol dihydrochloride hemimethanol solvate of melting point 232-233 C.

Ultraviolet: sh. 228 (8,400); sh. 234.5 (6,850); max. 270.5 (980); sh. 278 (915).

A nalysis.CalCd. for C21H34N204 /2 (percent): C, 55.24; H, 8.19; Cl, 15.17; N, 5.99. Found (percent): C, 54.90; H, 8.05; Cl, 15.30; N, 6.58.

The dihydrochloride above (1 g.) was treated with the calculated amount of aqueous sodium hydroxide solution and the mixture was extracted with methylene chloride. The methylene chloride extract was evaporated and the thus-obtained residue was recrystallized twice from methanol to give a (3,4,5-trimethoxyphenyl)-2-(4-methyl-lpiperazinyl) cyclohexanemethanol.

EXAMPLE 37 p-Methoxyphenyl 2-piperidino-l-cyclohexen-l-yl ketone In the manner given in Example 31, 23.2 g. (0.1 mole) of 2-(p-methoxybenzoyl)cyclohexanone was heated with 25.5 g. (0.3 mole) of piperidine in 800 ml. of toluene in the presence of 0.67 g. of p-toluenesulfonic acid to give p-methoxyphenyl 2-piperidino-l-cyclohexen-1-yl ketone.

EXAMPLE 38 Cis-A-ap-methoxyphenyl -2-piperidino cyclohexanemethanol A solution of p-methoxyphenyl 2 piperidino-l-cyclohexenl-yl ketone (obtained from a synthesis of the same hydrogenated in the presence of 1 g. of platinum oxide scale as shown in Example 37) in 300 ml. of ethanol was under an initial hydrogen pressure of 51 pounds. Two

molar equivalents of hydrogen were absorbed during a period of 2.5 hours. The mixture was filtered through Filtercel diatomaceous earth. The filtrate was then evaporated to dryness and the residue dissolved in 250 ml. of ether. The ether solution upon standing produced crystals which were recovered by filtration and Washed with ether. One g. of material was obtained having a melting point 152168 C. This material after recrystallization from methanol-ether was found to be the p-toluenesulfonic acid salt of cis-A-a-(p-methoxyphenyl)-2-piperidinocyclohexanemethanol of melting point 182l83 C.

Ultraviolet: 7\ max. 223 (21,800); sh. 256 (705); sh. 262 (980); sh. 268 (1,360); 275 (1,530); 282 (1,280).

Analysis.-Calcd. for C25H3qNO5S (percent): C, 65.66; H, 7.84; N, 2.95; S, 6.74. Found (percent): C, 65.27; H, 7.88; N, 2.89,; S, 6.86.

The ethereal filtrate above was stirred with 200 ml. of 10% aqueous acetic acid for /2 hour. The aqueous layer was separated, then extracted once with ether, and the ether extract discarded. The aqueous layer was then cooled, basified with aqueous sodium hydroxide solution and extracted with methylene chloride (four portions of 75 ml. each). The extracts were combined, washed with water, saturated salt solution, dried by passing the solution through anhydrous sodium sulfate and evaporated to give 22.5 g. of oily material. This material was recrystallized from petroleum ether to give 21.4 g. (71% yield) of cis-A a (p-methoxyphenyl)-2-piperidinocyclohexanemethanol of melting point 78-80 C.

Ultraviolet: A max. 225 (11,500); 275 (1,500); 283 (1,300).

Analysis.Calcd. for C H NO (percent): C, 75.20; H, 9.63; N, 4.62. Found (percent): C, 75.17; H, 9.88; N, 4.47.

Treating cis A-u-(p-methoxyphenyl-Z-piperidinocyclohexanemethanol with ethereal hydrogen chloride gave cis A 0c (p methoxyphenyl)-2-piperidinocyclohexanemethanol hydrochloride of melting point 235-236 C.

'In subsequent examples, compounds in difierent isomeric forms will appear, e.g., p-methoxyphenyl 2-piperifdinocyclohexyl ketone can be in cis or trans isomeric orms:

The above configurations are simplified. For example, a

truer representation of the cis form above would be the Configurations X and Y below.

cis trans l l l l l l F l l 'In the Configuration X the p-methoxybenzoyl group (at 1) is attached by an axial bond (a) to the cyclohexane moiety (chair form) and the piperidino group (at 2) by an equatorial bond (e). While this would indicate the existence of a cis isomer with reversed grouping, i.e., p-methoxybenzoyl on an equatorial bond and piperidino on an axial bond, such an isomer is thermodynamically less stable under ordinary conditions. However, the optical isomers (Y) and (X) of the cis form are stable and thus the simplified cis configuration represents a mixture of (X) and (Y). In the trans form, the equatorialequatorial positions of the vicinal substituents is the thermodynamically stable configuration and thus only one trans-p-methoxyphenyl 2-piperidinocyclohexyl ketone consisting of two optical forms, as for the cis compound, is obtained.

1 7 EXAMPLE 39 Cis-p-methoxyphenyl Z-piperidinocyclohexyl ketone A mixture of 139 g. (0.6 mole) of Z-(p-methoxybenzoyl)cyclohexanone, 153 g. (18 moles) of piperidine, 4800 ml. of toluene and 4.02. g. of p-toluenesulfonic acid monohydrate was refluxed for 20 hours in a vessel equipped with an azeotropic separator. A total of 10.1 ml. of water was collected. The reaction mixture was evaporated to dryness on a steam bath to give a residue which was dissolved in 1200 ml. of ethanol and the thus-obtained solution was divided into four equal parts. Each part was hydrogenated in the presence of 1.5 g. of platinum oxide at an initial pressure of 50 pounds of hydrogen. Hydrogenation was stopped after the uptake of 1 molar equivalent. The time required for this procedure was 25 minutes to 55 minutes. Thereafter, the combined mixture was filtered through diatomaceous earth, and the solution was evaporated to dryness. A deep yellow oil was obtained which was dissolved in 1200 ml. of ether and allowed to stand for minutes. The mixture was thereupon filtered and a precipitate was collected weighing 5.3 g. The ethereal filtrate was stirred with 1 l. of 10% aqueous hydrochloric acid for 45 minutes. The acidic layer was separated, filtered and basified with aqueous sodium hydroxide solution. The resulting oil which solidified after a short time was extracted with methylene chloride (five portions of 200 ml. each), the extracts were combined, washed with water, then with saturated salt solution, dried over anhydrous sodium sulfate and evaporated to give a crude product of 116 g. Recrystallization of this crude product from petroleum ether gave 75 g. (42% yield) of colorless needles of cis-p-methoxyphenyl 2-piperidinocyclohexyl ketone having a melting point of 86-- 88 C. Further recrystallization from petroleum ether for analytical purposes gave cis-p-methoxyphenyl 2-piperidinocyclohexyl ketone of melting point 86.5-88 C.

Ultraviolet: 7\ max. 217 (11,850); 273 (15,800); 278 (15,500).

Analysis.-Calcd. for C H NO (percent): C, 75.71; H, 9.03; N, 4.65. Found (percent): C, 76.19; H, 9.19; N, 4.88.

EXAMPLE 40 Trans-p-methoxyphenyl Z-piperidinocyclohexyl ketone A solution of 68.3 g. (0.227 mole) of cis-p-methoxyphenyl Z-piperidinocyclohexyl ketone was refluxed for 68 hours in 683 ml. of piperidine. The reaction mixture was thereupon evaporated to dryness to give 55 g. of a residual oil which was dissolved in 500 ml. of ether and extracted with four portions of 100 ml. each of 10% aqueous acetic acid. The acid extracts were combined, cooled in ice and basified with 20% aqueous sodium hydroxide solution and thereupon extracted with four portions of 150 ml. each of methylene chloride. The methylene chloride extracts were combined, washed with saturated salt solution, dried over anhydrous sodium sulfate and evaporated to give 22 g. of a colorless solid which was crystallized from 150 ml. of petroleum ether (boiling range from 3060 C.) to give 12.05 g. of trans-p-methoxyphenyl 2-piperidinocyclohexyl ketone of melting point 100-101 C. A second crop of 3.5 g. of the same material was also obtained; a total of 23% yield.

Ultraviolet: A max. 216 (12,900); 271 (15,350).

Analysis.Calcd. for C19H27NO2 (percent): C, 75.71; H, 9.03; N, 4.65. Found (percent): C, 75.28; H, 8.66; N, 4.62.

The original ether layer above contained also l-(pmethoxybenzoyl)-l-cyclohexene, a yellow oil boiling at 145-155 C.

Analysis.-Calcd. for C H O (percent): C, 77.75; H, 7.46. Found (percent): C, 77.99; H, 7.57.

Treatment of 3.45 g. of 1-(p-methoxybenzoyl)-1-cyclohexene with 20 ml. of piperidine on the steam bath for a period of 8 hours produced 36 mg. of trans-p-methoxyl 8 phenyl Z-piperidinocyclohexyl ketone of melting point 99- 101 C.

EXAMPLE 41 CiS-A-oc- (p-methoxyphenyl) -2-piperidinocyclohexanemethanol A solution of cis-p-methoxyphenyl Z-piperidinocyclohexyl ketone (3.01 g.; 0.01 mole) in ml. of ethanol was subjected to hydrogenation in the presence of platinum oxide (0.3 g.) at an initial pressure of 53 pounds of hydrogen. One molar equivalent was absorbed in 25 hours. The mixture was filtered, and the filtrate was evaporated to dryness, giving 3.1 g. of an oily material. A 2.9 g. portion of this oil was chromatographed over g. of Florisil (anhydrous magnesium silicate) using 150 ml. portions of an eluant of 6% acetone-94% Skellysolve B hexanes. The first four fractions containing 0.126 g. were discarded. The next eight fractions (150 ml. each using an eluant of 12% acetone-88% Skellysolve B hcxanes gave 2.294 g. of solid melting at 81-82 C. Fractions 13-l6 (150 ml. each) using an eluant of 25% acetone-75% Skellysolve B hexanes gave 0.309 g. of solid material melting at 81-82" C. The solids were combined and recrystallized from petroleum ether (boling range 30-60 C.) to give in two crops 2.4 g. of cis-A-a- (p-rnethoxyphenyl -2 piperidinocyclo-hexanemethanol of melting point 8182.50 C.

Since the carbon atom of the methanol group of oc-(P- methoxyphenyl) 2 piperidinocyclohexanemethanol is asymmetric, it is obvious that besides the cis-A-alcohol, the cis-B-alcohol is possible (Example 42).

EXAMPLE 42 Cis-A- and cis-B-a- (p-methoxy)-2-piperidinocyclohexanemethanol Solid cis p methoxyphenyl 2 piperidinocyclohexyl ketone (3.01 g.; 0.01 mole) was added to an ice-cooled solution of sodium borohydride (3 g.) in 100 ml. of ethanol. The reaction mixture was then stirred at room temperature (22-25 C.) for a period of 16 hours. It was evaporated to dryness in vacuo at 40 C. To the residue was added 100 ml. of water, and the mixture was then stirred for 30 minutes. The resulting oil was extracted three times with ether. The ether extracts were combined, washed with water, the water discarded, then washed with four 25-ml. portions of 10% aqueous acetic acid. The acidic extract was washed once with ether, and the ether discarded. It was then cooled in ice and basified with 15% sodium hydroxide solution. The reaction mixture was then extracted three times with ether, the extracts combined, washed with water, then with saturated salt solution, dried over anhydrous sodium sulfate and evaporated to give 3 g. of an oil. The oily material was crystallized from 50 ml. of petroleum ether (boiling range 3060 C.) to give 1.8 g. of cis A 0c (p-methoxyphenyl)-2-piperidinocyclohexanemethanol, melting point 7880 C.

The filtrate was evaporated to dryness, and the residue was chromatographed on 60 g. of Florisil (anhydrous magnesium silicate). The column of Florisil was eluted twice with 150-ml. portions of an eluant consisting of 6% acetone and 94% Skellysolve B hexanes; four times with 150-ml. portions of an eluant consisting of 12% acetone and 88% Skellysolve B hexanes; and finally three times with 150-ml. portions of a 20% acetone-80% Skellysolve B hexanes solution, giving 0.576 g. of cis-A-alcohol, which after recrystallization from petroleum ether had a melting point of 8081 C. Elution with 50% acetone-50% Skellysolve B hexanes (four portions of 150 ml. each) and acetone (two portions of 250 ml. each) gave 0.316 g. of cis B-a-(p-methoxyphenyl)-2-piperidinocyclohexanemethanol, which after recrystallization from ether weighed 0.1 g. and had a melting point of 135-136 C.

These cis alcohols A and B can also be produced from cis-p-methoxyphenyl Z-piperidinocyclohexyl ketone by reduction with lithium aluminum hydride.

EXAMPLE 43 Cis-A- and cis-B-a-(p-methoxyphenyl)-2-piperidinocyclohexanemethanol A solution of 0.9 g. (3 mmoles) of cis-p-methoxyphenyl Z-piperidinocyclohexyl ketone in 25 ml. of ether was added dropwise during 5 minutes to a solution containing 1 g. of lithium aluminum hydride in 100 ml. of ether. The mixture was stirred during a period of 22 hours and was then decomposed by successive addition of 1 ml. of water, 1 ml. of 15% aqueous sodium hydroxide and 3 ml. of water. The resulting suspension was stirred for a period of 2 hours. It was then filtered and the solid washed with ether. The combined filtrate and washings were extracted with three portions of 30 ml. of each of aqueous acetic acid, and the combined acidic extracts were backwashed once with ether. The acidic extract was then basified with aqueous sodium hydroxide and extracted three times with ether. The combined ether extracts were washed with water, saturated salt solution, and dried by passage through anhydrous sodium sulfate. The resulting dried solution was evaporated to give 0.77 g. of a colorless oil. This oil was chromatographed over 35 g. of Florisil (anhydrous magnesium silicate) by eluting with an eluant consisting of 6% acetone and 94% Skellysolve B hexanes. The first four fractions of 150 ml. each gave 0.607 g. (67% yield) of cis-A-a-(p-methoxyphenyl)-2- piperidinocyclohexanemethanol (melting point 80-81 C.). Further elution with an eluant consisting of 12% acetone and 88% Skellysolve B hexanes gave, in four 150-ml. fractions, 0.209 g. of CiS-B-oc- (p-methoxyphenyl)- 2 piperidinocyclohexanemethanol of melting point 134- 1.35 C. (23% yield).

EXAMPLE 44 Trans-C-a-(p-methoxyphenyl)-2-piperidinocyclohexanemethanol In the manner given in Example 41, trans-p-methoxyphenyl Z-piperidinocyclohexyl ketone (3.01 g.; 0.01 mole) was hydrogenated in ethanol solution in the presence of 0.5 g. of platinum oxide catalyst at 53 pounds initial hydrogen pressure. The solution after 138 minutes of hydrogenation was filtered through Filtercel diatomaceous earth. The filtrate was evaporated giving 3 g. of a solid of melting point 141-145 C. This solid was crystallized from methanol to give 2.5 g. of colorless needles of trans-C-a- (p-methoxyphenyl)-2 piperidinocyclohexanemethanol of melting point 148149 C. A second crop of 0.25 g. of product was obtained from the filtrate; the total yield was 91%.

Ultraviolet: 225 (12,150); 275 (1,500); 281 (1,300).

Analysis.Calcd. for C H No (percent): C, 75.20; H, 9.63; N, 4.62. Found (percent): C, 75.18; H, 9.81;

EXAMPLE 45 Trans-D-a-(p-methoxyphenyl)-2-piperidinocyclohexanemethanol A solution of 0.060 g. (1.98 mmoles) of trans-C-a-(pmethoxyphenyl)-2-piperidinocyclohexanemethanol in 4 m1. of trifluoroacetic acid was stirred for 20 minutes. It was cooled in ice, 10 ml. of water was added, followed by 10 ml. of 20% aqueous sodium hydroxide solution. The

mixture was thereupon extracted twice with methylene chloride. The combined extract was washed with water, saturated salt solution, dried by passage through anhydrous sodium sulfate and evaporated to give 0.6 g. of a colorless solid of melting point 129-140 C. Crystallization from methanol yielded 0.325 g. of recovered starting material of melting point 145-147 C. The filtrate was evaporated to dryness and the residue was chromatographed over 15 g. of Florisil (anhydrous magnesium silicate). The column containing the Florisil was eluted with 400 ml. of a solution containing 6% acetone and 94% Skellysolve B hexanes. The filtrates from the solution were combined and evaporated, and the residue was recrystallized from petroleum ether (boiling range 30-60 C.) to give 77 mg. of a product melting at 81-82 C., namely trans-D-a-(p-methoxyphenyl) 2 piperidinocyclohexanemethanol.

Ultraviolet: 226 (11,000); 276 (1,650); 282 (1,450).

Analysis.-Calcd. for C H NO (percent): C, 75.20; H, 9.63; N, 4.62. Found (percent): C, 75.19; H, 9.63; N, 4.55.

EXAMPLE 46 Trans-C- and trans-D-a- (p-methoxyphenyl)-2- piperidinocyclohexanemethanol A solution of trans-p-methoxyphenyl Z-piperidinocyclohexyl ketone (23.9 g.; 0.0795 mole) in 575 ml. of ether was added to a solution of 24 g. of lithium aluminum hydride in 2400 ml. of ether over a period of 30 minutes. The mixture was then stirred for about 20 hours. It was thereupon decomposed successively with 24 ml. of water, 24 ml. of 15% aqueous sodium hydride and 72 ml. of water. The resulting mixture was filtered and the cake was washed with ether. The combined filtrate and washings Were evaporated to dryness to give 22.5 g. of a colorless oily solid which upon crystallization from 75 ml. of ethanol gave 13.4 g. of trans-C-a-(p-methoxyphenyl)-2- piperidinocyclohexanemethanol of melting point 145- 146 C.

The filtrate was evaporated to dryness. The residue was dissolved in 50 ml. of methylene chloride and chromatographed over 460 g. of Florisil (anhydrous magnesium silicate). The column containing the Florisil was eluted with 750 ml. of an eluant consisting of 3% acetone and 97% Skellysolve B hexanes. This fraction yielded 81 mg. of solid which was discarded; thereupon were taken nineteen 250-ml. portions using an eluant consisting of 6% acetone and 94% Skellysolve B hexanes. These fractions were combined and evaporated to give 5.31 g. of solid melting at 82 C. Further elution with an eluant consisting of 15% acetone and Skellysolve B hexanes (4 fractions of 250 ml. each) gave 0.535 g. of solid melting at 8081 C. Recrystallization of the combined material from petroleum ether afforded 4.6 g. of trans-D-a-(pmethoxyphenyl) 2 piperidinocyclohexanemethanol of melting point 8182 C.

Nuclear magnetic resonance spectrum (in CD01 showed methoxy at 229 c.p.s.; broad band for benzylic hydrogen centered at 278.5 c.p.s.

EXAMPLE 47 A solution was prepared having 30.3 g. (0.1 mole) of cis-A-a-(p-methoxyphenyl) 2 piperidinocyclohexanemethanol in 200 ml. of trifluoroacetic acid, under cooling with ice. The mixture was then stirred at room temperature for 20 minutes, giving a greenish solution which was again cooled in ice. To this solution was added 150 g. of ice followed by 500 ml. of water and then 500 ml. of 20% aqueous sodium hydroxide. The mixture was stirred for 15 minutes and was thereupon extracted with five portions of 200 ml. each of methylene chloride. The methylene chloride extracts were combined, washed with water, saturated salt solution, then dried by passage through anhydrous sodium sulfate and evaporated to dryness to give 28 g. of a colorless oil. This oil was dissolved in 1 l. of ether and the solution was concentrated to about 200 ml. at which point crystallization commenced. The solution was allowed to cool and was then filtered to provide 16.4 g. of cis-B-a-(p-methoxyphenyl) 2 piperidinocyclohexanemethanol as needles melting at 133134 C. From second and third crops, additional 6.8 g. of CiS-B-oc-(p-mthOXY- phenyl)-2-piperidinocyclohexanemethanol was obtained.

Analysis.Calcd. for C H NO (percent): C, 75.20; H, 9.63; N, 4.62. Found (percent): C, 74.96; H, 9.62; N, 4.55.

EXAMPLE 48 a-(3,4,5-trimethoxyphenyl) -2-hexahydro-1H-azepinl-yl cyclohexanemethanol hydrochloride OCH; Ii l OCHaHCl (5 E H H OCH;

A mixture of 35 g. (0.12 mole) of 2-(3,4,5-trimethoxybenzoyl)cyclohexanone, 35.6 g. (0.36 mole) of hexamethyleneimine, 960 ml. of toluene and 0.8 g. of p-toluenesulfonic acid was refluxed for 7.5 hours in a nitrogen atmosphere in a vessel equipped with an azeotropic separator. A total of 1.8 ml. of Water was collected. The mixture was thereupon evaporated to dryness, the residue was dissolved in 250 ml. of ethanol and hydrogenated in the presence of 1.2 g. of platinum oxide at an initial pressure of 51.5 pounds of hydrogen. Two molar equivalents of hydrogen were absorbed during 5 hours. The reaction mixture was then filtered through diatomaceous earth (Filtercel), and the filtrate was evaporated to dryness. The thus-obtained residue was dissolved in 400 ml. of ether. The ether solution was stirred with 400 ml. of hydrochloric acid for 0.5 hours, and the resulting suspension was filtered. The obtained solid was washed with ether to give 18.2 g. of material. This material was crystallized from 250 ml. of methanol to give 16.4 g. of a-(3,4,5-trimethoxyphenyl)-2-(hexahydro-1H-azepin 1 yl)cyclohexanemethanol hydrochloride of melting point 244- 246" C.

Ultraviolet: sh. 228 (8,250); 268 (757); 276 (608).

Analysis.Calcd. for C H NO -HCl (percent): C, 63.83; H, 8.77; Cl, 8.56; N, 3.38. Found (percent): C, 63.95; H, 9.13; Cl, 8.47; N, 3.58.

Workup of the aqueous hydrochloric acid filtrate above provided another 0.7 g. of ot-(3,4,5-trimethoxyphenyl)-2 (hexahydro-lH-azepin-l-yl)cyclohexanemethanol hydrochloride of melting point 242-243 C.; thus a total yield of 34%.

EXAMPLE 49 Cis A-oc- (p-methoxyphenyl) -2- (hexahydrodH-azepin-lyl) cyclohexanemethanol hydrochloride (A) l-hexamethyleneimino 1 cyclohexene.A mixture of 196 g. (2 moles) of cyclohexanone, 396 g. (4 moles) of hexamethyleneimine, 3 l. of benzene and 2.5 g. of p-toluenesulfonic acid was refluxed for 24 hours, separating 34 ml. of water with an azeotropic separator. Distillation of the material provided 293.7 g. (82 percent yield) of l-hexamethylene-imino-l-cyclohexene having a boiling point of 138140 C. at 16 mm. [this enamine was reported by Nightingale et al., J. Org. Chem. 28, 642 (1963)].

(B) Cis A a-(p-methoxyphenyl)-2-(hexahydro-IH- azepin-l-yl)-cyclohexanemethanol hydrochloride.To a solution of 107.4 g. (0.6 mole) of l-hexamethyleneiminol-cyclohexene in 252 ml. of chloroform (purified by passage through basic alumina) was added 60.6 g. (0.6 mole) of triethylamine at a temperature of 5 C. To the reaction mixture was added a solution of 102 g. (0.6 mole) of panisoyl chloride in 240' ml. of purified chloroform during a period of 2 hours while keeping the temperature between 5 to 10 C. A suspension resulted which was stirred for a period of about 20 hours at room temperature. The suspension was thereupon filtered, and the precipitate washed with ether, the ether wash being discarded. The precipitate was 46.8 g. of trieth'ylamine hydrochoride of melting point 25 3-254 C. The chloroform filtrate was evaporated to dryness. The resulting residue was dissolved in 900ml. of ethanol and hydrogenated in three portions, each in the presence of 1 g. of platinum oxide at a hydrogen pressure of about -52 pounds. After the absorption of about 80% of the hydrogen had taken place, the hydrogenation stopped and another '1 g. of platinum oxide was added. Two molar equivalents of hydrogen were absorbed during 22 hours. The resulting thick suspension was filtered and th'e precipitate washed with ethanol. The moist cake was refluxed with 1500 ml. of ethanol, filtered and allowed to crystallize. The first crop of crystals amounted to 80.7 g. of cis-A-a-(p-methoxyphenyl)-2-(hexahydro-1H-azepinl-yl) cyclohexanemethanol hydrochloride of melting point of 230231 C. A second crop of 20 g. was also collected. Further recrystallization did not change the melting point of the product.

Ultraviolet: max. 226 (12,150); 276 (1,550); 282 1,350).

Analysis.Calcd. for C H NO' -HC1 (percent): C, 67.87; H, 9.12; Cl, 10.02; N, 3.97. Found (percent): C, 67.27; H, 9.14; C], 9.97; N, 4.03.

EXAMPLE 50 a-(p-Trifiuoromethylphenyl)-2-(hexahydro-1H-azepinl-yl) cyclohexanemethanol hydrochloride In the manner given in Example 49, 0.1 mole of triethylamine and 0.1 mole of l-hexamethyleneimino-lcyclohexene was reacted in chloroform solution with 0.1 mole of p-trifluoromethylbenzoyl chloride. The resulting product was hydrogenated in 300 ml. of methanol in the presence of 1 g. of platinum oxide. Two molar equiva lents of hydrogen were absorbed in 3.5 hours. The hydrogenation reaction mixture was filtered through diatomaceous earth (Filtercel) and the filtrate evaporated to drymess. The resulting solid was suspended in 200 ml. of

EXAMPLE 51 oz- (p-Chlorophenyl -2- (hexahydro-lH-azepinl-yl) cyclohexanemethanol hydrochloride In the manner given in Example 49, 0.1 mole of triethylamine, 0.1 mole of l-hexamethyleneimino-l-cyclohexene and 0.1 mole of p-chlorobenzoyl chloride were reacted in purified chloroform and the resulting product hydrogenated for 5.5 hours in 300 ml. of methanol in the presence of 1 g. of platinum oxide. The resulting suspension was diluted with 400 ml. of ethanol, heated to reflux, filtered and the solution allowed to crystallize. Filtration yielded 12.25 g. of a.-(p-chlorophenyl)-2-(hexahydro-1H- azepin-l-yl)cyclohexanemethanol hydrochloride of melting point 274-275 C.

Ultraviolet: A max. 221 (10,000); sh. 226 (8,200); 252 (182); 258 (210); 267 (260); 275 (193).

Analysis.--Calcd. for C H ClNO-Hcl (percent): N, 3.91. Found (percent): N, 3.98.

EXAMPLE 52 a-Phenyl-Z-(hexahydro-lH-azepin-1-yl)cyclohexanemethanol hydrochloride In the manner given in Example 49, 0.1 mole of triethylamine, 0. 1 mole of l-hexamethyliminol-cyclohexone and 0.1 mole (14 g.) of benzoyl chloride were reacted and the reaction product hydrogenated in methanol in the presence of platinum oxide for a period of 2.5 hours. The mixture was filtered, evaporated to dryness and the solid residue Was supended in 200 ml. of ether and 200 ml. of 10 percent aqueous acetic acid. The mixture was stirred for 0.5 hour and the resulting suspension filtered yielding a solid which was washed with water followed by ether. The thus-obtained product, 3.6 g., was recrystallized from methanol to give 2.8 g. of a-phenyl-2-(hexahydro-lH- azepin-l-yl)cyclohexanemethanol hydrochloride of melting point 276-277 C.

Ultraviolet: A max. 247 (107); 252 (130); 257 (178); 263 (130); 2 67 (91).

AnaIysis.Calcd. for C H NO-HCl (percent): C, 70.45; H, 9.34; Cl, 10.95; N, 4.33. Found (percent): C, 70.22; H, 8.94; Cl, 11.03; N, 4.45.

EXAMPLE 5 3 u- (3 ,4-methylenedioxyphenyl -2-( hex ahydro-l H-azepin- 1-yl cyclohexanemethanol hydrochloride A solution of piperonyloyl chloride in 120 ml. of chloroform was added during 1.5 hours with cooling and stirring to a solution of 1-hexamethyleneimino-l-cyclohexene (53.6 g.; 0.3 mole) and 30.3 g. (0.3 mole) of triethylamine in 126 ml. of chloroform at a temperature below C. The reaction mixture was then stirred for about 20 hours at a temperature between 23-26 C. The thus-obtained suspension was filtered to give 23 g. of triethylamine hydrochloride melting at 252-254 C. The filtrate was evaporated to dryness, the residue was dissolved in 600 ml. of ethanol and hydrogenated in the presence of 3 g. of platinum oxide at an initial pressure of 52.5 pounds of hydrogen. After 6 hours, a 1 g. quantity of platinum oxide catalyst was added and hydrogenation continued for another 16 hours. The resulting suspension was filtered and the solid, consisting of the product and catalyst, was refluxed in 1800 ml. of ethanol; this suspension was filtered, evaporated to 900 ml. and allowed to crystallize, yielding 50 g. of ot-(3,4-methylenedioxyphenyl)-2-(hexahydro-lI-I-azepin-l-yl) cyclohexanemethanol hydrochloride of melting point 235-236 C.

Work-up of the filtrate by evaporation and stirring with 400 ml. of 10 percent aqueous acetic acid and 450 ml. of ether gave another 10 g. of solid material which after recrystallization from ethanol gave 5 g. of a-(3,4-methylenedioxyphenyl)-2-(hexahydro-lH-azepin-l yl)cyclohexanemethanol hydrochloride of melting point 233234 C.

Ultraviolet: A max. 235 (4,150); 286 (4,050).

Analysis.Calcd. for C H NO -HCl (percent): C, 65.29; H, 8.22; CI, 9.64; N, 3.81. Found (percent): C, 65.18; H, 8.38; Cl. 9.93; N, 379.

The above compound is useful as a diuretic and oral antidiabetic agent.

EXAMPLE 54 00- 3,4-dimethoxyphenyl -2- (hexahydrolH-azepinl-yl) cyclohexanemethanol hydrochloride In the manner given in Example 53, l-hexamethyleneimino-l-cyclohexene was reacted with 3,4dimethoxybenzoyl chloride (53.6 g.; 0.3 mole) in the presence of triethylamine. The resulting product was hydrogenated in the presence of platinum oxide and the mixture was worked up as in Example 53 giving 52.2 g. of a-(3,4-dimethoxyphenyl -2- (hexahydrolH-azepin- 1 yl cyclohexanemethanol hydrochloride of melting point 225-228 C. in the first crop. Additional material was obtained by the work-up of filtrates with acetic acid and ether. A total yield of about 50 percent was obtained. The analytical sample, prepared by recrystallization from ethanol, gave w(3,4-dimethoxyphenyl)-2-(hexahydro-1H-azepin-1 yl) cyclohexanemethanol hydrochloride of melting point 225- 226 C.

Ultraviolet: max. 230 (8,550); 279 (2,950); sh. 285 (2,550).

Analysis.-Calcd. for C H NO -HCl (percent): C, 65.69; H, 8.93; Cl, 9.24; N, 3.65. Found (percent): C, 65.88; H, 9.19; Cl, 9.30; N, 3.95.

EXAMPLE 55 Cis-B-ot- (p-methoxyphenyl -2- hexahydro- 1 H-azepin-lyl)cyclohexanemethanol and the hydrochloride thereof To 240 ml. of trifiuoroacetic acid, cooled to 5 C. was added, all at once, 38 g. (0.12 mole) of cis-Aax-(p-methoxyphenyl)-2-(hexahydro-lH-azepin-l yl)cyclohexanemethanol with stirring. The mixture was kept stirring for 20 minutes whereby the temperature reached about 40 C. Thereupon, the solution was cooled, ice was added, followed by 600 m1. of water and then 600 ml. of 20 percent aqueous sodium hydroxide. The mixture was then extracted with five 200-ml. portions of methylene chloride. The extracts were combined, washed with saturated salt solution, dried by passing through anhydrous sodium sulfate, and the filtrate evaporated to give 37.9 g. of a yellowish oil. This oil was dissolved in ml. of petroleum ether (boiling range 3060 C.) and allowed to crystallize in the refrigerator overnight; 13.6 g. of crystals were recovered by filtration. These crystals were recrystallized from 50 ml. of ether to give 10.1 g. of cis-B-a-(p-methoxyphenyl)-2 (hexahydro 1H azepin 1 yl)cyclohexane methanol of melting point 94-95 .5 C.

Ultraviolet: A max. 225 (12,750); 275 (1,550); 281 (1,350).

Analysis.Calcd. for C H NO (percent): C, 75.67; H, 9.84; N, 4.41. Found (percent): C, 75.86; H, 9.85; N, 4.48.

The hydrochloride of cis-B-ot-(p-methoxyphenyl)-2- (hexahydro-lH-azepin 1 yl)cyclohexanemethanol was prepared with 1.5 N ethereal hydrogen chloride. After two crystallizations from methanol-ether, colorless needles were obtained melting at 188189 C.

Ultraviolet: A max. 226 (12,700); 275 (1,450); 281 (1,250).

Analysis.-Calcd. for C H NO -HCl (percent): C, 67.87; H. 9.12; Cl, 10.02; N, 3.97. Found (percent): C, 67.24; H, 9.36; Cl, 9.76; N, 3.96.

Oxidation of both cis-A- and cis-B-a-(p-methoxyphenyl)-2-(hexahydro-lH-azepin 1 yl)cyclohexanemethanol with chromic acid (Jones reagent) gave the same cis-pmethoxyphenyl 2 (hexahydro-lH-azepin-l-yl)cyclohexyl ketone as a pale yellow oil. Treating this oil with hydrogen chloride in ether provided after recrystallizing from methanol-ether the hydrochloride of cis-p-methoxyphenyl 2-(hexahydro-1H-azepin-1-yl)cyclohexy1 ketone of melting point 164-165 C.

Analysis.Calcd. for c ,H ,No -Hc1 (percent): C, 68.26; H, 8.59; Cl, 10.08; N, 3.98. Found (percent): C, 67.92; H, 8.55; Cl, 10.06; N, 4.05.

EXAMPLE 56 a-(3,4,5-trirnethoxyphenyl)-2-piperidinocycloheptane methanol hydrochloride (A) l-piperidino-l-cycloheptene.A mixture of 224.2 g. (2 moles) of cycloheptanone, 340 g. (4 moles) of piperidine, 400 ml. of benzene and 2.2 g. of p-toluenesulfonic acid was refluxed for a period of 16 hours in a nitrogen atmosphere, using an azeotropic separator. A total of ml. of water was collected. Since this was less than the calculated amount of water produced during the reaction, the separator was replaced with a 'Soxhlet extractor containing 322 g. of crystalline sodium aluminum silicate, Na [(Al O (SiO [Linde molecular sieve, Type 4A; see The Merck Index, Merck and Co., Inc., 1960, Seventh Edition, page 1592], and the mixture was refluxed for three days. After the solvent was removed by distillation from the reaction mixture, 319.7 g. of l-piperidino-l-cycloheptene of boiling point 130131 C. at 17 mm. (89% yield) was obtained.

(B) or (3,4,5-trimethoxyphenyl)-2-piperidinocycloheptane-methanol hydrochloride.-In the manner given in Example 49, Part B, 23 g. (0.1 mole) of 3,4,5-trimethoxybenzoyl chloride, 17.9 g. (0.1 mole) of l-piperidino-l-cycloheptene and triethylamine (0.1 mole) were reacted at low temperature in a chloroform solution. The resulting product was hydrogenated in methanol for period of 3 hours during which 2 molar equivalents of hydrogen were consumed. The resulting reaction mixture was then filtered and evaporated, and the residue stirred with 150 ml. of water and 150 ml. of methylene chloride for a period of 0.5 hour. The methylene chloride layer was separated and stirred with 250 ml. of aqueous hydrochloric acid for /z hour. The resulting suspension was filtered and the solid washed with water to give 7.5 g. of a-(3,4,5-trimethoxyphenyl)-2-piperidinocycloheptane-methanol hydrochloride of melting point 237-238 C. This material was recrystallized from methanol to give ot-(3,4,5-trimethoxyphenyl)- 2-piperidinocycloheptane-methanol hydrochloride of melting point 243-244 C.

Ultraviolet: sh. 266 (8,250); sh. 234 (6,800); A max. 270 (782); sh. 278 (546).

Analysis.- Calcd. for C H NO -HCI (percent): C, 63.82; H, 8.77; CI, 8.57; N, 3.38. Found (percent): C, 63.43; H, 8.85; Cl, 8.66; N, 3.20.

The work-up of the methylene chloride layer gave 1.5 g. of cycloheptyl 3,4,5-trimethoxyphenyl ketone of melting point 7677 C. in colorless crystalline plates.

Analysis.Calcd. for C H O (percent): C, 69.83; H, 8.27. Found (percent): C, 69.64; H, 8.24.

EXAMPLE 5 7 OC- 3,4,5-trimethoxyphenyl -2- 1-pyrrolidinyl)cyclohexanemethanol and hydrochloride A mixture of 17.5 g. (0.06 mole) of 2-(3,4,5-trimethoxybenzoyl)cyclohexanone, 12.8 g. (0.18 mole) of pyrrolidine and 480 ml. of benzene was refluxed for 1.25 hours using an azeotropic separator; 1.5 ml. of water was collected. The mixture was evaporated to dryness to give a yellow oil. A small sample was crystallized twice from ether to give yellow prisms melting at 118-120 C. and constituting 3,4,5-trimethoxyphenyl 2-(1-pyrrolidinyl)-1- cyclohexen-l-yl ketone.

Ultraviolet: in ether A max. 262 (11,500); 358 (5,500); in ethanol sh. 220 (17,000); 269 (7,700); 372

( Analysis.-Calcd. for C H NO (percent): C, 69.54; H, 7.88; N, 4.06. Found (percent): C, 69.91; H, 8.08; N, 3.76.

The crude 3,4,5-trimethoxyphenyl 2-(l-pyrrolidinyl)-1- cyclohexen-l-yl ketone was dissolved in 250 ml. of ethanol and hydrogenated in the presence of 0.6 g. of platinum oxide. Two molar equivalents of hydrogen were taken up in 6 hours. The mixture was then filtered through diatomaceous earth and the filtrate evaporated to dryness. The residue was stirred with 200 ml. of 10% aqueous hydrochloric acid and 250 ml. of ether for 0.5 hour. The aqueous layer was separated, extracted with ether, basified with sodium bicarbonate and extracted with four 125-m1. portions of methylene chloride. The methylene chloride extracts were combined, washed with water, then with saturated salt solution, dried by passing through anhydrous sodium sulfate and evaporated to give 16.5 g. of solid. This solid was recrystallized from ether to give 9.7 g. of u-(3,4,5-trimethoxyphenyl) 2 (1-pyrrolidinyl)cyclohexanemethanol of melting point 121-122 C. A second crop of 2 g. of the alcohol was obtained with a melting point of 119-120 C. The total yield was 56%.

Ultraviolet: sh. 226 (9,200); A max. 269 (744); sh. 280 (542).

Analysis.-Calcd. for C H NO (percent): C, 68.74; H, 8.94; N, 4.01. Found (percent): C, 68.61; H, 8.84; N, 4.17.

In a similar manner 3,4,5-trimethoxyphenyl 2-(1-pyrrolidinyl)-1-cyclohexen-1-yl ketone [prepared from 0.1 mole of 2-(3,4,5-trimethoxybenzoyl)cyclohexanone] was hydrogenated in ethanol in the presence of 1 g. of 5% rhodium on alumina catalyst. The hydrogenation continued for 30 hours. The mixture was then filtered, evaporated to dryness, and the residue was dissolved in ether and treated with ethereal hydrogen chloride to give 5.2 g. of solid. This solid was recrystallized from isopropyl alcohol to give 4.6 g. of ot-(3,4,5-trimethoxyphenyl)-2-(l-pyrrolidinyl)-cyclohexanemethanol hydrochloride of melting point 216217 C.

AnaIysis.-Calcd. for C H NO -HCl (percent): C, 62.24; H, 8.36; Cl, 9.19; N, 3.63. Found (percent): C, 62.31; H, 8.82; Cl, 9.15; N, 3.65.

EXAMPLE 5 8 3,4,5 trimethoxy oz (2-piperidinocyclopentyl)benzyl alcohol [a-(3,4,5-trimethoxyphenyl)-2-piperidinocyclopentanemethanol] (A) 3,4,5 trimethoxyphenyl 2 piperidinocyclopentyl ketone.A solution of 15.1 g. (0.1 mole) of l-piperidinol-cyclopentene was added, in a nitrogen atmosphere, with ice cooling, to a solution of 10.1 'g. (0.1 mole) of triethylamine in 42 ml. of chloroform (purified by passage through a column of basic alumina). To this solution was added a solution of 23.0 g. (0.1 mole) of 3,4,5-trimethoxybenzoyl chloride in 40 ml. of chloroform, over a period of 1.5 hours, while the temperature of the reaction mixture was kept at 5-10 C. The mixture was then stirred overnight at room temperature (22-25 C.) and was filtered to give 6.91 g. of triethylamine hydrochloride. The filtrate was evaporated to dryness at 50 C. The residue was disolved in 250 ml. of ethanol, 12 g. (0.2 mole) of acetic acid and 1 g. of platinum oxide were added and hydrogenation was carried out at an initial pressure of 51 pounds. Two moles of hydrogen were taken up during 1 hour and 28 minutes; more than of the calculated hydrogen was absorbed in the first half hour. The mixture was then filtered and evaporated to dryness. A mixture of ml. of ether and 100 ml. of 10% aqueous hydrochloric acid was added, and the obtained reaction mixture was stirred for 1.5 hours. The layers were separated and the aqueous layer was extracted once with ether. The ether extracts were washed with water to give the neutral layer. The acidic layer Was cooled in ice and basified with 20% aqueous sodium hydroxide. It was extracted twice with ether, the combined ether extract was washed with Water, saturated salt solution, dried by passage through anhydrous sodium sulfate and evaporated to give 14.6 g. of a brown oil which solidified on standing in vacuo overnight. The solid was dissolved in 150 ml. of petroleum ether (boiling range between 30-60 C.) and 20 ml. of ether and cooled with ice for 2 hours. The resulting suspension was decanted, thus providing solid A and filtrate B. Filtrate B was evaporated to about half the volume and cooled. The resulting solid, 1.2 g. of melting point -130 C., was removed by filtration. Recrystallization of this solid from ether gave colorless needles of melting point 133.5134.5 C. The melting point of this material was not changed by recrystallization from ether. Ultraviolet, infrared and NMR spectra and also carbon,

27 hydrogen and nitrogen analysis indicated that this product was a mixture.

Solid A and the residue from filtrate B were combined to give 13.3 g. of a yellow solid. This solid was dissolved in 50 ml. of benzene and chromatographed over 400 g. of neutral alumina, taking six benzene fractions of 250 ml. each. Fraction 2 contained 2.378 g. of material which was crystallized from 20 ml. of Skellysolve B hexanes to give 1.5 g. of 3,4,5-trimethoxyphenyl 2-piperidinocyclopentyl ketone of melting point 79-80 C.

Ultraviolet: max. 217 (29,400); 283 (10,700).

Analysis.Calcd. for C H NO (percent): C, 69.13; H, 8.41; N, 4.03. Found (percent): C, 69.21; H, 8.58; N, 4.14.

The above neutral layer contained a solid fraction of 8.78 g. which after recrystallization from Skellysolve B hexanes gave 6.8 g. of cyclopentyl 3,4,5-trimethoxyphenyl ketone of melting point 46-47.5 C.

(B) 3,4,5 trimethoxy-a-(Z-piperidinocyclopentyl)benzyl alcohol.-A solution of 1.2 g. (3.48 mmoles) of 3,4,5- trimethoxyphenyl Z-piperidinocyclopentyl ketone in 25 m1. of ether was added over a period of 5 minutes to a solution of 1.2 g. of lithium aluminum hydride in 100 ml. of ether, and the mixture was stirred for 21 hours. It was then decomposed by successive addition of 1.2 g. of water, 1.2 ml. of 15% aqueous sodium hydroxide and 3.6 ml. of water. The thus-obtained reaction mixture was stirred for a period of 2 hours giving a suspension. This suspension was filtered and the solid washed with ether. The ether washing and the ether filtrate were combined, dried by passage through anhydrous sodium sulfate and evaporated to give 1.2 g. of an oil. The oil was chromatographed over 48 g. of Florisil (anhydrous magnesium silicate). Elution with five 100-ml. portions of a mixture consisting of acetone and 90% Skellysolve B hexanes gave 0.136 g. of an oil. Elution with five portions of 100 ml. each of 20% acetone-80% Skellysolve B hexanes mixture gave 0.582 g. of oil. After standing in vacuo for one week, the oil crystallized to give a solid of melting point 85-88 C. This solid was recrystallized from ether-petroleum ether to give a 3,4,5-trimethoxy-a-(Z-piperidinocyclopentyl)benzyl alcohol melting at 9 192 C.

Ultraviolet: sh. 224 (9,100); sh. 234; sh. 269 (849); sh. 278 (660).

Analysis.Calcd. for C H NO (percent): C, 68.74; H, 8.94; N, 4.01. Found (percent): C, 68.49; H, 8.98; N, 4.25.

Further elution with 30% acetone-70% Skellysolve B hexanes (five portions of 100 ml. each) gave 0.140 g. and elution with 50% acetone-50% Skellysolve B hexanes mixture (five portions of 100 ml. each) gave 0.170 g. of solids. A 75% acetone-25% Skellysolve B hexanes mixture (five portions of 100 ml. each) gave 0.087 g. and elution with acetone (two portions of 100 ml. each) gave 0.154 g. of solids. These solid fractions were combined and recrystallized from petroleum ether (boiling range 30-60" C.) to give 0.44 g. of crystals, which after recrystallization from a 1:1 mixture of ether-petroleum ether (boiling range of petroleum ether 30-60 0.), gave a material melting at 119120 C. which was another isomer of 3,4,5 trimethoxy a-(Z-piperidinocyclopentyl)benzyl alcohol.

EXAMPLE 59 3,4,5-trimethoxy oz (2 pyrrolidinocyclopentyl)-benzyl alcohol [a-(3,4,5-trimethoxyphenyl) 2 pyrrolidinocyclopentanemethanol] A mixture of 8.35 g. (0.03 mole) of 2-(3,4,5-trimethoxybenzoyl)cyclopentanone, 6.5 g. (0.09 mole) of pyrrolidine, 240 ml. of benzene and 0.2 g. of p-toluenesulfonic acid was refluxed under a nitrogen atmosphere for 21 hours using an azeotropic separator; 0.5 ml. of water was collected. The solution was evaporated to dryness, 3,4,5-trimethoxyphenyl 2-pyrrolidino 1 cyclopentenl-yl ketone being obtained as a residue. This residue was dissolved in 100 ml. of methanol and hydrogenated in the presence of 0.3 g. of platinum oxide at an initial pressure of 54 pounds. One molar equivalent of hydrogen was taken up over a period of 4 hours whereupon the hydrogenation was stopped. The mixture was filtered through diatomaceous earth, and the filtrate evaporated to dryness, 3,4,5 trimethoxyphenyl 2-pyrrolidinocyclopentyl ketone being obtained as a residue. One-half of this product (5 g.; 0.015 mole) was dissolved in 100 m1. of benzene. This solution was aded during 10 minutes to a solution of 5 g. of lithium aluminum hydride in 200 ml. of ether, and the mixture was refluxed with stirring for a period of 3 hours. It was then decomposed by successively adding 5 ml. of water, 5 ml. of 15 aqueous sodium hydroxide and 15 ml. of water. The suspension was filtered, and the solid washed with ether. The filtrate and the ether washings were combined, extracted with 10% hydrochloric acid (four portions of 50 ml. each) and the acidic extracts were basified by the addition of aqueous sodium hydroxide. The basi-fied solution was extracted with four portions (each 50 ml.) of methylene chloride. The methylene chloride extracts were combined, washed with water, then with saturated salt solution, dried by passage through anhydrous sodium sulfate and evaporated to give 4.5 g. of a yellow oil. This yellow oil was dissolved in 20 ml. of methylene chloride and chromatographed over 200 g. of Florisil (anhydrous magnesium silicate). The elution was carried out with five portions of 200 ml. each of 50% acetone-50% Skellysolve B hexanes. The eluates were concentrated to give 0.41 g. of solid which was recrystallized from Skellysolve B hexanes to give 3,4,5-trimethoxy-a-(2 pyrrolidinocyclopentyl)benzyl alcohol of melting point 86 C.

Ultraviolet: sh. 227 (9,300); max. 269 (788); sh. 278 (573). NMR showed H on carbon bearing the OH as a doublet centered at 316.5 c.p.s. (i=3 c.p.s.).

Analysis.Calcd. for C H NO (percent): C, 68.03; H, 8.71; N, 4.18. Found (percent): C, 67.50; H, 8.73; N, 4.43.

Elution of the above column with five portions of 200 ml. each of acetone gave after evaporation 0.58 g. of a solid, which was crystallized from ether and thereupon from tetrahydrofuran-Skellysolve B hexanes to give isomeric 3,4,5 trimethoxy a (2 pyrrolidinocyclopentyl) benzyl alcohol of melting point 147-148 C.

Ultraviolet: sh. 225 (8,950); A max. 270 (1,100); Sh. 227 (567). NMR showed H on carbon bearing the OH as a doublet centered at 291 c.p.s. (i=5 c.p.s.).

Analysis.-Calcd. for C H NO' (percent): C, 68.03; H, 8.71; N, 4.18. Found (percent): C, 67.70; H, 8.90; N, 4.25.

EXAMPLE 60 p-Ethoxyphenyl Z-piperidino-1cyclohexen-l-yl ketone In the manner given in Example 31, 2 (p-ethoxybenzoyl)cyclohexanone was reacted with piperidine in the presence of p-toluenesulfonic acid acid to give pethoxyphenyl Z-piperidino-l-cyclohexen-l-yl ketone.

EXAMPLE 61 p-Benzyloxyphenyl 2-pyrrolidino-l-cyclohexenl-yl ketone In the manner given in Example 31, Z-(p-benzyloxybenzoyl)-cyclohexanone was reacted with pyrrolidine in the presence of p-toluenesulfonic acid to give p-benzyloxyphenyl 2-pyrrolidino-l-cyclohexen-l-yl ketone.

EXAMPLE 62 p-Benzyloxyphenyl 2-piperidino-l-cyclohexen- 1-yl ketone In the manner given in Example 31, 2 (p benzyloxybenzoyl)-cyclohexanone was reacted with piperidine in the presence of p-toluenesulfonic acid to give p-benzyloxyphenyl Z-piperidino-l-cyclohexen-l-yl ketone.

29 EXAMPLE 63 p-(2-hydroxyethoxy)phenyl Z-piperidino-lcyclohexenl-yl ketone In the manner given in Example 31, 2 [p (2 hydroxyethoxy)benzoyl] cyclohexanone was reacted with piperidine in the presence of p-toluenesulfonic acid to give p-(2-hydroxyethoxy)phenyl 2-piperidino 1 cyclohexen-l-yl ketone.

EXAMPLE 64 o-Methoxyphenyl Z-piperidino-l-cyclohexen- 1-y1 ketone In the manner given in Example 31 (2-(o-methoxybenzoyDcyclohexanone was reacted with piperidine in the presence of p-toluenesulfonic acid to give o-methoxyphenyl 2-piperidino-l-cyclohexen-l-yl ketone.

EXAMPLE 65 o-Hydroxyphenyl 2-piperidino-l-cyclohexen- 1-y1 ketone In the manner given in Example 31, 2-(o-hydroxybenzoyl)cyclohexanone was reacted with piperidine in the presence of p-toluenesulfonic acid to give o-hydroxyphenyl 2-piperidino-l-cyclohexen-l-yl ketone.

EXAMPLE 65A p-Hydroxyphenyl 2-piperidinol-cyclohexen- 1-y1 ketone In the manner given in Example 31, 2-(p-hydroxybenzoyl)cyclohexanone was reacted with piperidine in the presence of p-toluenesulfonic acid to give p-hydroxyphenyl 2-piperidino-l-cyclohexen-l-yl ketone.

EXAMPLE 66 2-methoxy-4-methylphenyl 2-piperidino-1-cyclohexen-l-yl ketone In the manner given in Example 31, 2-(2-methoxy-4- methylbenzoyl)cyclohexanone was reacted with piperidine in the presence of p-toluenesulfonic acid to give 2-methoxy 4 methylphenyl 2 piperidino 1 cyclohexenl-yl ketone.

EXAMPLE 67 3,5-dimethyl-4-methoxyphenyl 2-piperidino-1-cyclohexen-l-yl ketone In the manner given in Example 31, 2-(3,5-dimethyl-4- methoxybenzoyl)cyclohexanone was reacted with piperidine in the presence of p-toluenesulfonic acid to give 3,5- dimethyl-4-methoxyphenyl 2-piperidino-l-cyclohexen-1-yl ketone.

EXAMPLE 68 p-Trifiuoromethylphenyl Z-piperidino-l-cyclohexenl-yl ketone In the manner given in Example 31, Z-(p-trifluoromethylbenzoyl)cyclohexanone was reacted with piperidine in the presence of p-toluenesulfonic acid to give ptrifiuoromethylphenyl 2-piperidino-l-cyclohexen-l-yl ketone.

EXAMPLE 69 p-Allyloxyphenyl 2-piperidino-l-cyclohexen-l-yl ketone In the manner given in Example 31, 2-(p-al1yloxybenzoyl)cyclohexanone was reacted with piperidine in the presence of p-toluenesulfonic acid to give p-allyloxyphenyl 2-piperidin0-l-cyclohexen-l-yl ketone.

EXAMPLE 70 p-(Methylcarbamoyloxy)phenyl 2-piperidino-1- cyclohexen-l-yl ketone In the manner given in Example 31, 2-[p-(methylcarbamoyloxy)benzoyl]cyclohexanone was reacted with piperidine in the presence of p-toluenesulfonic acid to give p-(methylcarbamoyloxy)phenyl 2-piperidino-1-cyclohexen-l-yl ketone.

EXAMPLE 71 3,4-methylenedioxyphenyl 2- (hexahydro-lH-azepin-lyl)-1-cyclohexen-1-yl ketone In the manner given in Example 31, 2-(3,4-mcthylenedioxybenzoyl) cyclohexanone was reacted with hexamethyleneimine in the presence of p-toluenesulfonic acid to give 3,4-methy1enedioxyphenyl 2- (hexahydro-lH-azepin-l-yl)-1-cyclohexen-1-yl ketone.

EXAMPLE 72 p-Chlorophenyl 2-(2-isopropylpyrrolidino) -1-cyclohexenl-yl ketone In the manner given in Example 31, Z-(p-chlorobenzoyl)cyclohexanone was reacted with 2-isopropylpyrrolidine in the presence of p-toluenesulfonic acid to give p-chlorophenyl 2-(Z-isopropylpyrrolidino) 1 cyclohexen-l-yl ketone.

EXAMPLE 73 p-Hydroxyphenyl 2-octamethyleneiminol-cyclohexenl-yl ketone In the manner given in Example 31, 2-(p-hydroxybenzoy1)cyc1ohexanone was reacted with octamethyleneimine in the presence of p-toluenesulfonic acid to give p-hydroxyphenyl 2 octamethyleneimino-l-cyclohexen-1- yl ketone.

In the same manner given in Example 31, other kcto compounds of Formula II can be obtained by reacting a 1,3-diketone of Formula I with a heterocyclic amine in the presence of an acid catalyst, e.g., benzenesulfonic acid, p-toluenesnlfonic acid, rn-chlorobenzenesulfonic acid and the like. Representative compounds thus obtained include:

o-methylphenyl Z-pyrrolidino-l-cyclohexen-l-yl ketone;

p-methylphenyl 2-pyrrolidino-l-cyclohexen-l-yl ketone;

2-methoxy-4-methylphenyl 2-morpholino-l-cyclohexenl-yl ketone;

2-hydroxy-5-chlorophenyl 2-homom0rpholino-1- cyclohexene-l-yl ketone;

p-(carboxymethoxy)phenyl 2-(3,6-dimethylhexamethyleneimino)-1-cyclohexen-1-yl ketone;

3,4-methylenedioxyphenyl 2-(2-methylpiperidino)-1- cyclohexen-l-yl ketone;

p-ethoxyphenyl 2-pyrrolidino-l-cyclohepten-l-yl ketone;

2,3,4-trimethoxyphenyl Z-piperidino-l-cycloocten-l-yl ketone;

3,5-diiodophenyl 2-(3-methylpiperidino)-1-cyclohexen- 1-yl ketone;

2-methoxy-4-chlorophenyl 2-piperidino-l-cyclohexenl-yl ketone;

Z-methyl-4-trifluoromethylphenyl Z-piperidino-lcyclohexen-l-yl ketone;

3,4-dipropylphenyl 2-pyrrolidino-l-cyclohepten-l-yl ketone;

2,5-dichlorophenyl 2-(hexahydro-lH-azepin-l-yl)-1- cyclohepten-l-yl ketone;

3,4-dich1orophenyl 2- 3-methylpiperidino) -1-cycloocten- 1-yl ketone;

p-propoxyphenyl 2-(4-butylpiperazino)-1-cycloocten-1- yl ketone;

2,5 -diiodophenyl 2- (Z-methylhexamcthyleneimino) -1- cyclohepten-l-yl ketone;

3-fiuorophenyl 2-pyrrolidino-I-cyclopenten-l-yl ketone;

2-hexylphenyl 2-piperidino-l-cyclopenten-1-yl ketone;

B-pentylphenyl 2-piperidino-l-cyclohexen-l-yl ketone;

Z-butylphenyl 2-morpholino-l-cyclohexen-l-yl ketone;

2-propylpheny1 2- 1,2,3,4-tetrahydro-1-quinoly1)-lcyclohepten-l-yl ketone;

3-ethylphenyl Z-piperidino-l-cycloocten-l-yl ketone;

2-methoxy-5-bromophenyl 2-pyrrolidino-l-cyclopenten- 1-y1 ketone;

phenyl-Z-octamethyleneimino-l-cycloocten-l-yl ketone; phenyl 2-(2,3,G-trimethylmorpholino -1-cycloheptenlyl ketone;

and the like.

EXAMPLE 74 a- (p-Ethoxyphenyl) -2-piperidinocyclohexanemethanol hydrochloride In the manner given in Example 32, p-ethoxyphenyl Z-piperidino-l-cyclohexen-l-yl ketone was hydrogenated in the presence of platinum oxide to give a-(p-ethoxyphenyl)-2-piperidinocyclohexanemethanol recovered as hydrochloride; melting point 221222 C.

EXAMPLE 75 ot-(p-Benzyloxyphenyl)-2-pyrrolidinocyclohexanemethanol In the manner given in Example 32, p-benzyloxyphenyl 2-pyrrolidino-l-cyclohexen-l-yl ketone was hydrogenated in the presence of platinum oxide to give a- (p-benzyloxyphenyl -2-pyrrolidinocyclohexanemethanol.

EXAMPLE 76 Cis-A-a- (p benzyloxyphenyl -2-piperidinocyclohexanemethanol In the manner given in Example 32, p-benzyloxyphenyl 2-piperidino-l-cyclohexene-l-yl ketone was hydrogenated in the presence of platinum oxide to give CiS-A-oc-(P- benzyloxyphenyl) 2 piperidinocyclohexanemethanol of melting point 148.5l49.5 C.

In the same manner, catalytic hydrogenation of cis-pbenzyloxyphenyl Z-piperidinocyclohexyl ketone (Example 88) gives the same product.

EXAMPLE 76A ClS'B-Ot- (p-benzyloxyphenyl -Z-piperidinocyclohexanemethanol and hydrochloride thereof In the manner given in Example 47, cis-A-a-(p-benzyloxyphenyl)-2-piperidinocyclohexanemethanol was converted by means of trifluoroacetic acid to cis-B-a-(p-benzyloxyphenyl)-2-piperidinocyclohexanemethanol of melting point 129-130 C.

This base was treated with ethereal hydrogen chloride, to obtain cis-B-ot-(benzyloxyphenyl)-2-piperidinocyclohexanemethanol hydrochloride of melting point 238- 240 C.

EXAMPLE 77 (1- [p- 2-hydroxyethoxy) phenyl] -2-piperidinocyclohexanemethanol hydrochloride EXAMPLE 78 ot-(o-Methoxyphenyl)-2-piperidinocyclohexanemethanol hydrochloride In the manner given in Example 32, o-methoxyphenyl 2-piperidino-l-cyclohexen-l-yl ketone was hydrogenated in the presence of platinum oxide to give a-(o-methoxyphenyl)-2-piperidinocyclohexanemethanol recovered as hydrochloride.

32 EXAMPLE 79 a- (o-Hydroxyphenyl -2-piperidinocyclohexanemethanol In the manner given in Example 32, o-hydroxyphenyl 2-piperidino-l-cyclohexen-l-yl ketone was hydrogenated in the presence of platinum oxide to give a-(ohydroxyphenyl) 2 piperidinocyclohexanemethanol of melting point 122-1225 C.

The above compound is useful as a diuretic.

EXAMPLE 79A CiS-A-a- (p-hydroxyphenyl -2-piperidinocyclohexanemethanol and hydrochloride thereof In the manner given in Example 32, p-hydroxyphenyl Z-piperidino-l-cyclohexen-l-yl ketone was hydrogenated in the presence of platinum oxide to give ClS-A-u-(P-IIY- droxyphenyl)-2-piperidinocyclohexanemethanol of melting point 179-l80 C.

This base was treated with ethereal hydrogen chloride to obtain cis-A-a-(p-hydroxyphenyl)-2-piperidinocyclohexanemethanol hydrochloride of melting point 204- 204.5 C.

These above compounds are useful as diuretics.

EXAMPLE 79B Cis-B-a- (p-hydroxyphenyl)-2-piperidinocyclohexanemethanol In the manner given in Example 47, cis-A-a-(p-hydroxyphenyl)-Z-piperidinocyclohexanemethanol was converted by means of trifiuoroacetic acid to CiS-B-oc-(P-hY- droxyphenyl)-2-cyclohexanemethan0l of melting point 182183 C.

The above compound is useful as a diuretic.

EXAMPLE 80 or (2-methoxy-4-methylphenyl) -2-piperidinocyclohexanemethanol hydrochloride In the manner given in Example 32, 2-methoxy-4- methylphenyl 2-piperidino-I-cyclohexen-1-yl ketone was hydrogenated in the presence of platinum oxide to give u-(2-methoxy-4-methylphenyl) 2 piperidinocyclohexanemethanol recovered as hydrochloride; melting point 25l252 C.

EXAMPLE 81 a- 3,5-dimethyl-4-methoxyphenyl -2-piperidinocyclohexanemethanol hydrochloride In the manner given in Example 32, 3,5-dimethyl-4- methoxyphenyl 2-piperidino-l-cyclohexen-l-yl ketone was hydrogenated in the presence of platinum oxide to give u-(3,S-dimethyl-4-rnethoxyphenyl) 2 piperidinocyclohexanemethanol recovered as hydrochloride.

EXAMPLE 82 ap-Trifiuoromethylphenyl -2-piperidino cyclohexanemethanol hydrochloride In the manner given in Example 32, p-trifiuoromethylphenyl Z-piperidino-l-cyclohexen-l-yl ketonew as hydrogenated in the presence of platinum oxide to give a-(p-trifluoromethylphenyl) 2 piperidinocyclohexanemethanol recovered as hydrochloride.

EXAMPLE 83 a- (p-Propoxyphenyl)-2-piperidinocyclohexanemethanol hydrochloride In the manner given in Example 32, p-allyloxyphenyl Z-piperidino-l-cyclohexen-l-yl ketone was hydrogenated in the presence of platinum oxide to give a-(p-propoxyphenyl)-2-piperidinocyclohexanemethanol recovered as hydrochloride.

3 EXAMPLE 83A Cis-A- ap-allyloxyphenyl) -2-piperidino cyclohexanemethanol A mixture of 11.6 g. (0.04 mole) of cis-A-a-(p-hydroxyphenyl)-Z-piperidinocyclohexanemethanol and 1.8 g. of a 53.3 percent mineral oil dispersion of sodium hydride (0.04 mole of sodium hydride) in 100 ml. of dimethyl sulfoxide was stirred for a period of 1 hour. A solution of 4.9 g. (0.0404 mole) of allyl bromide in 15 ml. of ether was added to the mixture above during a period of 15 minutes and the obtained reaction mixture was stirred for 3 hours at room temperature and then poured in 1 l. of ice water. A white solid separated which was extracted three times with ether. The ether extracts were combined, washed with water and saturated sodium chloride solution, dried over anhydrous sodium sulfate and evaporated to give a residue. This residue was twice recrystallized from ether-pentane to give a total of 11.8 g. (89%) of cis-A-a-(p-allyloxyphenyl)-2-piperidinocyclohexanemethanol of melting point 70-72 C.

Analysis.--Calcd. for C H NO (percent): C, 76.55; H, 9.48; N, 4.25. Found (percent): C, 76.79; H, 9.10; N, 4.20.

The above compound is useful as an oral antidiabetic agent.

EXAMPLE 84 oc- [p- (Methylcarbamoyloxy phenyl] -2-piperidinocyclohexanemethanol hydrochloride In the manner given in Example 32, p- (methylcarbamoyloxy)-phenyl 2-piperidino 1 cyclohexen-l-yl ketone was hydrogenated in the presence of platinum oxide to give a-[p-(methylcarbamoyloxy)-phenyl]-2-piperidinocyclohexanemethanol recovered as hydrochloride.

EXAMPLE 85 a-(3,4-methylenedioxyphenyl)-2-piperidinocyclohexanemethanol hydrochloride In the manner given in Example 32, 3,4-methylenedioxyphenyl 2piperidino-l-cyclohexen-l-yl ketone was hydrogenated in the presence of platinum oxide to give a (3,4-methylenedioxyphenyl)-2-piperidinocyclohexanemethanol recovered as hydrochloride.

EXAMPLE 86 a- (p-ChlorophenyD-Z- (2-isopropylpyrrolidino)cyclohexanemethanol hydrochloride In the manner given in Example 32, p-chlorophenyl 2-(2-isopropylpyrrolidino)-1-cyclohexen-1-yl ketone was hydrogenated in the presence of platinum oxide to give a-(p-chlorophenyl) 2 (2-isopropylpyrrolidino)cyclohexanemethanol recovered as hydrochloride.

EXAMPLE 87 ap-Hydroxyphenyl) -2-octamethyleneiminocyclohexanemethanol hydrochloride In the manner given in Example 32, p-hydroxyphenyl 2-octamethyleneiminol-cyclohexen-l-yl ketone was hydrogenated in the presence of platinum oxide to give a-(p-hydroxyphenyl) 2 octamethyleneiminocyclohexanemethanol recovered as hydrochloride.

In the same manner given in Example 32, hydrogenating other keto compounds of Formula II in the presence of platinum oxide gives the substituted methanol's of the Formula IV recovered as hydrochlorides. Representative hydrochlorides, thus obtained, include: the hydrochlorides of a-(o-methylphenyl)-2-pyrro1idinocyclohexanemethanol;

nt- (p-methylphenyl) -2-pyrrolidino cyclohexanemethanol;

u.- (2-methoxy-4-methylphenyl) -2-morpholinocyclohexanemethanol;

oc- (2-hydroxy-5-chlorophenyl -2-homomorpholinocyclohexanemethanol;

a- [p- (carboxymethoxy phenyl] -2- (3 ,G-dimethylhexamethyleneimino cyclohexanemethanol;

oc- 3 ,4-methylenedioxyphenyl) -2- (2-methylpiperidino) cyclohexanemethanol;

a- (p-ethoxyphenyl) -2-pyrrolidino cycloheptanemethanol;

a- (2,3 ,4-trimethoxyphenyl -Z-piperidinocyclooctanemethanol;

u- 3,5 -diiodophenyl) -2- (3-methylpiperidino cyclohexanemethanol;

OL- (2-methoxy-4-chlorophenyl) -2-piperidino cyclohexanemethanol;

oc- Z-methyl-4-trifluoromethylphenyl) -2-piperidino cyclohexanemethanol;

a- 3 ,4- dip ropylphenyl) -2-pyrrolidinocycloheptanemethanol;

00- (2,5-dichlorophenyl) -2-hexahydrolH-azepinl-yl) cycloheptanemethanol;

a- (3 ,4-dich1orophenyl -2- (3 -methylpiperidino) cyclooctanemethanol;

u- (p-propoxyphenyl) -2- 4-butylpip erazino) cyclooctanemethanol;

06- (2,5 -diio dophenyl -2- (Z-methylhexamethyleneimino) cycloheptanemethanol;

oc- (3 -fluorophenyl) -2-pyrrolidinocyclopentanemethanol;

a- (2-hexylphenyl) -2-pip eridinocyclopentanemethanol;

a- 3 -pentylphenyl -2-piperidino cyclohexanemethanol;

cz- (Z-butylphenyl) -2-morpholinocyclohexanemethanol;

oc- (2-propylphenyl -2- 1 ,2,3,4-tetrahydrol-quinolyl) cycloheptanemethanol;

u- 3-ethylphenyl) -2-piperidino cyclooctanemethanol;

ot-(2-methoXy-5-br0m0pheny1) -2-pyrrolidinocyclopentanemethanol;

u-phenyl-2-octamethyleneimino cyclooctanemethanol;

a-phenyl-2- (2, 3 6-trimethylmorpholino) cycloheptanemethanol; and the like.

EXAMPLE 88 Cis-p-benzyloxyphenyl 2-piperidinocyclohexyl ketone In the manner given in Example 39, p-benzyloxyphenyl 2-piperidino-l-cyclohexen-l-yl ketone dissolved in ethanol was hydrogenated in the presence of platinum oxide until one molar equivalent of hydrogen was consumed (42 minutes) to give cis-p-benzyloxyphenyl 2-piperidinocyclohexyl ketone of melting point 87.588.5 C.

Analysis.-Calcd. for C H NO (percent): C, 79.53; H, 8.28; N, 3.71. Found (percent): C, 78.88; H, 8.27; N, 3.65.

In the same manner given in Example 39, selective catalytic reduction (preferably with platinum oxide) of other compounds of Formula II produces cis-ketones of Formula III, e.g.,

cis-3,4,5-trimethoxyphenyl Z-piperidinoeyclohexyl ketone;

cis-p-ethoxyphenyl Z-piperidinocyclohexyl ketone;

cis-p-(2-hydroxyethoxy)phenyl Z-piperadinocyclohexyl ketone;

cis-p-trifluoromethylphenyl 2-piperidinocyclohexyl ketone;

cis-p-chlorophenyl 2-(Z-isopropylpyrrolidino)cyclohexyl ketone;

sis-3,4-methylenedioxyphenyl 2-(hexahydro-1H-azepin- 1-yl)cyclohexyl ketone;

cis-2,3,4-trimethoxyphenyl Z-piperidinocyclooctyl ketone;

cis-3 ,4-dichlorophenyl 2- 3-methylpiperidino) cyclooctyl ketone;

cis-2,5-dichlorophenyl 2-hexahydro-lH-azepinyl-l-yl) cycloheptyl ketone; and the like.

In the manner given in Example 41, other cis-alcohols can be obtained by hydrogenating a compound of Formula II or III in the presence of a catalyst such as platinum oxide, palladium or the like. Representative compounds thus obtained include: cis-u-(p-methylphenyl)-2- piperidinocyclohexanemethanol, melting point 102103 C., as hydrochloride melting point 251253 C.; ClS-Ot-(P- methoxyphenyl) 2- (4-methyl-1-piperazinyl)cyclohexanemethanol, melting point 132133 C.; cis-a-(p-methoxyphenyl) 2 (4-methylpiperidino)cyclohexanemethanol, melting point 9394 C.; cis-u-(p-methoxyphenyl)-2- morpholinocyclohexanemethanol, melting point Ill-112 C.; cis a (p-methoxyphenyl)-2-(3-azabicyclo[3.2.2]nonan 3 yl)cyclohexanemethanol, melting point 114.5- 115.5 C.; cis-a-(p-methoxyphenyl)-2-pyrrolidinocyclohexanemethanol, melting point 146147 C.; ClS-cc-(P- methoxyphenyl) 2 (Z-methylpiperidino)cyclohexanemethanol, as perchlorate, melting point 108111 C.; cisa (p-methoxyphenyl) -3,3-dimethyl-6-piperidinocyclohexanemethanol, melting point 133-135 C.; cis-a-(4-methoxy 3,5 dimethylphenyl)-2-(hexahydro-1H-azepin-1- y1)cyclohexanemethano1, as hydrochloride, melting point 247-248 C.; cis-ot-(2,4-dimethylphenyl)-2-piperidinocyclohexanemethanol, as hydrochloride, melting point 239- 240 C.; cis-ot-(2,5-dichlorophenyl)-2-heptamethyleneiminocycloheptanemethanol; cis a (2-butylphenyl)-2-morpholinocyclohexanemethanol; ci's ot-(2-propylphenyl)-2- (1,2,3,4-tetrahydro-l-quinolyl) cycloheptanemethanol; cisor (2,3,4 trimethoxyphenyl) 2-piperidinocyclooctanemethanol; and the like.

EXAMPLE 89 1-[2- (a,3,4,5-tetramethoxybenzyl)cyclohexyl]piperidine hydrochloride (isomer cis-A hydrochloride) A solution of 4 g. (0.01 mole) of a-(3,4,5-trimethoxyphenyl)-2-piperidinocyclohexanemethanol hydrochloride in 160 ml. of water was basified by adding suflicient 10% aqueous sodium hydroxide solution. This solution was extracted three times with 100 ml. of methylene chloride. The methylene chloride solution was evaporated, leaving an oily free base.

A solution of the free base a.-(3,4,5-trimethoxyphenyl)- 2-piperidinocyclohexanemethanol in 25 ml. of ether was added to 100 ml. of liquid ammonia containing 0.01 mole of sodium amide and the mixture was stirred for a period of 50 minutes, while cooling in Dry Ice-acetone. A solution of 1.42 g. (0.01 mole) of methyl iodide in 5 I111. of ether was then added during 5 minutes; the Dry Ice bath was removed and the mixture allowed to stir at room temperature for a period of 7 hours. It Was then allowed to evaporate overnight (about 20 hours). To this reaction mixture was then added 50 ml. of water, and the mixture was extracted with three portions of 50 ml. each of methylene chloride. The combined methylene chloride extracts were washed with water, saturated salt solution, dried by passing through anhydrous sodium sulfate and evaporated ,to give 3.6 g. of an oily product. The oil was dissolved in methylene chloride and chromatographed on 108 g. of Florisil (anhydrous magnesium silicate). The column of Florisil was eluted with four portions, each 200 ml., of a 3% acetone-97% Skellysolve B hexanes solution, yielding 1.80 g. of an oil after evaporation of the solvents. The oil was dissolved in ether and treated with ethereal hydrogen chloride to give 1.4 g. of material melting at 227-228 C. This material was recrystallized from methanol-ether to give 1-[2-(a,3,4,5-tetramethoxybenzyl)cyclohexyl]piperidine hydrochloride (isomer cis- A hydrochloride) of melting point 224225 C.

Ultraviolet: A max. 212 (33,400); sh. 235 (6,600); 271 (923); sh. 279 (646).

Analysis.--Calcd. for C H NO -HCl (percent): C, 63.82; H, 8.77; Cl, 8.56; H, 3.38. Found (percent): C, 63.70; H, 8.95; Cl, 8.25; N, 3.46.

EXAMPLE 90 idinocyclohexanemethanol (3.0 g.; 0.01 mole) in 50 ml. 7F

of methanol was treated with a solution of 5 g. of hydrogen chloride in ml. of methanol, and an additional 100 ml. of methanol was added. The solution was allowed to stand for 18 hours at about 25 C. and was then evaporated to dryness at 45 C. under reduced pressure. The oily residue was dissolved in 50 ml. of water; the solution was basified with aqueous sodium hydroxide solution and extracted with ether. The extract was washed with water, then with saturated sodium chloride solution, dried through anhydrous sodium sulfate, and evaporated to dryness, to obtain 3.0 g. yield) of cis-B-1-[2-(u,p-dimethoxy benzyl)cyclohexyl]piperidine of melting point 7577 C. Recrystallization from ethanol gave 2.3 g. of this compound, melting point 81-82 C. Ultraviolet: A max. 226

Analysis.-Calcd. for C H NO (percent): C, 75.67; H, 9.84; N, 4.41. Found (percent): C, 75.70; H, 10.06; N, 4.15.

A solution of 10.7 g. (0.0354 mole) of cis-B-1-[2-(zx,pdimethoxybenzyl)cyclohexylJpiperidine in 50 ml. of ether was treated With 40 ml. of 1.3 N ethereal hydrogen chloride solution. The resulting solid was crystallized from 25 ml. of methylene chloride and 50 ml. of ether to give 9.3 g. of cis-B- 1- 2- a,p-dimethoxybenzyl-cyclohexyl] piperidine hydrochloride of melting point 209-211 C.

Ultraviolet: A max. 227 (12,500); 275 (1,400); 281 1,200).

Analysis.Calcd. for C H NO -HCl (percent): C, 67.87; H, 9.11; Cl, 10.02; N, 3.96. Found (percent): C, 67.41; H, 9.31; Cl, 10.47; N, 3.83.

(B) In the manner given in Example 89, an ether solution of cis B a (p-methoxyphenyl)-2-piperidinocyclohexanemethanol was treated in liquid ammonia with sodium amide and methyl iodide. The cis-B-1-[2-(a,p-dimethoxybenzyl)cyclohexyl]piperidine thus obtained was identical with the compound prepared by the above methanol-hydrogen chloride etherification procedure.

EXAMPLE 91 Cis-B- 1- 2- u,p-dimethoxybenzyl cyclohexyl] piperidine N-oxide hydrate To an ice-cooled solution of 2.2 g. (7 mmoles) of cis- B-1-[2-(a,p-dimethoxybenzyl)cyclohexyl]piperidine in 50 ml. of methanol was added 2.4 g. (14 mmoles) of mchloroperbenzoic acid. The resulting colorless solution was allowed to stand in ice for 6 hours and then at room temperature (23 to 25 C.) for about 18 hours. It was evaporated to dryness at 35 C. to give an oily residue. To this residue was added 25 ml. of water followed by 25 ml. of 5% aqueous sodium hydroxide, and then the mixture was extracted three times with a total of ml. of methylene chloride. The methylene chloride extracts were combined, washed twice with saturated salt solution, dried by passage through anhydrous sodium sulfate and evaporated to give 2.5 g. of an oil. The oil was dissolved in 25 ml. of hot ethyl acetate (saturated with water), and the cloudy solution was filtered through a sinter funnel. The resulting clear solution was evaporated to 10 ml., cooled and seeded. The resulting crystals were recovered by filtration and washed with ether to give colorless prisms of cis B [2-(ot,p-dimethoxybenzyl)cyclohexyl]piperidine N-oxide hydrate melting at 108-1 10 C.

Ultraviolet: A max. 227 (12,750); 275 (1,400); 282

Analysis.-Calcd. for C H NO -H O (percent): C, 68.34; H, 9.46; N, 3.99. Found (percent): C, 68.66; H, 9.46; N, 3.96.

EXAMPLE 92 Cis-B- 1- [2- a,p-dimethoxybenzyl cyclohexyl] piperidine and its methiodide A solution of 4 ml. of butyl lithium (0.01 mole) in hexane was added during 2 minutes to a solution of 3.03 g. (0.01 mole) of cis-B-tx-(p-methoxyphenyl)-2- piperidinocyclohexanemethanol in 30 ml. of purified tetrahydrofuran. The mixture was stirred at room temperature for 30 minutes and then cooled in a Dry Ice bath at -70 C. To this solution was added a solution of methyl iodide (1.42 g.; 0.01 mole) in 10 ml. of tetrahydrofuran, dropwise, over a period of 10 minutes. The mixture was stirred at --70 C. for a period of 1.5 hours and then at room temperature for 19 hours. To the solution was thereupon added water (50 ml.) and the solution was then extracted with three portions of 75 ml. each of methylene chloride. The organic extracts were combined, dried by passage through anhydrous sodium sulfate and evaporated to give 2.7 g. of crude product. The crude product was dissolved in 20 ml. of methylene chloride and chromatographed over 135 g. of neutral alumina. The material was first eluted with eight portions of 250 ml. of a ether-95% Skellysolve B hexanes solution. After evaporation of the combined eluates, 1.523 g. of solid material, melting between 82-84" C., was obtained. Further elution with two portions of 250 ml. of 25% ether-75% Skellysolve B hexanes, with two portions of 250 ml. each of 50% ether-50% Skellysolve B hexanes and with two portions of 250 ml. each of 75% ether-25% Skellysolve B hexanes gave a total of 0.204 g. of solid material after evaporation of the combined eluates. The above fractions were all combined and recrystallized from ethanol to give 0.644 g. of cis-B-l-[2-(a,p-dimethoxybenzyl)cyclohexyl]piperidine of melting point 8485.5 C. This free base was identical with the free base obtained in Example 90, parts A and B.

Further elution of the column with 250 ml. of methanol gave 1.446 g. of material which was crystallized from methanol-ether overnight in the refrigerator to give 0.252 g. of the methiodide of cis-B-1-[2-(u,p-dimethoxybenzyl) cyclohexyl]piperidine, melting after another recrystallization from methanol-ether at 217218 C.

Ultraviolet: A max. 223 (24,000); 275 (1,390); 281 (1,280).

Analysis.Calcd. for C H IN0 (percent): C, 54,90; H, 7.46; I, 27.63; N, 3.05. Found (percent): C, 55.03; H, 7.68; I, 27.63; N, 3.23.

EXAMPLE 92A Cis-A- 1- [2- (a,p-dimethoxyb enzyl) cyclohexyl] pip eridine hydrochloride methanol solvate In the manner given in 'Example 89', an ether solution of cis-A-u-(p-methoxyphenyl)-2 piperidinocyclohexanemethanol was treated with a solution of sodium amide in liquid ammonia and thereupon with a solution of methyl iodide in ether at about 70 C. to give cis-A-1-[2-(a,p-dimethoxybenzyl)cyclohexylJpiperidine recovered as hydrochloride methanol solvate of melting point 196.5197.5 C.

Ultraviolet: 227 (11,400); 274 (1,380); 281 (1,200).

Analysis.-Calcd. for C H NO 'CH OH-HCl (percent): C, 65.34; H, 9.40; (31, 9.19; N, 3.63. Found (percent): C, 65.50; H, 9.28; Cl, 8.50; N, 4.03.

EXAMPLE 93 Trans-C- 1- [.2-(a,p-dimetlroxybenzyl) cyclohexyl piperidine A solution of butyl lithium in hexane (5.25 ml., containing 0.01 mole) was added during a period of minutes to a solution of u(p-methoxyphenyl)-2-piperidinocyclohexanemethanol (3.03 g.; 0.01 mole of the trans-C alcohol) in 40 ml. of tetrahydrofuran in a nitrogen atmosphere. The reaction mixture was then stirred for 45 minutes. It was cooled to -70 C. and thereto was added a solution of 1.41 g. (0.01 mole) of methyl iodide in 10 ml. of purified tetrahydrofuran over a period of 30 minutes. The mixture was then stirred at room temperature (about 25 C.) overnight for about 16 hours. The reaction mixture was thereupon evaporated to dryness and the resulting residue was dissolved in 50 ml. of water and 50 m1. of methylene chloride. The aqueous layer was extracted with methylene chloride and the methylene chloride extracts combined, washed with saturated salt solution, dried by passage through anhydrous sodium sulfate and evaporated, to give 3.2 g. of a crude product. The crude product was chromatographed over 155 g. of neutral alumina, using six portions of 150 ml. each of 6% ether-94% Skellysolve B hexanes solution. The eluates were evaporated to give 1.642 g. of an oily product which was crystallized from 5 ml. of methanol to give 1.2 g. of a product melting at 78- 79 C. Additional recrystallization gave pure trans-C-l- [2-(a,p-dimethoxybenzyl)cyclohexyl1piperidine of melting point 7980 C.

Ultraviolet: max. 225 (11,550); sh. 265 (1,150); 275, (1,550); 282 (1,350).

Analysis.Calcd. for C H NO (percent): C, 75.67; H, 9.84; N, 4.41. Found (percent): C, 75.80; H, 10.08; N, 4.71.

The same product was obtained when trans-C-et-(pmethoxyphenyl) 2 piperidinocyclohexanemethanol in methanol solution was treated with anhydrous hydrogen chloride in methanol solution and the resulting hydrochloride was treated with 20% aqueous sodium hydroxide.

EXAMPLE 94 Trans-D- 1 2- a,p-dimethoxybenzyl -cyclohexyl] piperidine A hexane solution of butyl lithium 5.25 ml.; 0.01 mole) was added during 10 minutes to a solution of trans-D-u- (pmethoxyphenyl)-2 piperidinecyclohexanemethanol (3.03 g.; 0.01 mole) in 30 ml. of purified tetrahydrofuran in a nitrogen atmosphere. The mixture was stirred for a period of 40 minutes, then cooled to 70 C. and a solution of 1.42 (0.01 mole) of methyl iodide in 10 ml. of purified tetrahydrofuran was added over a period of 30 minutes. The mixture was then stirred for 18 hours at room temperature, evaporated to dryness and the residue dissolved in 50 m1. of water and 50 ml. of methylene chloride. The aqueous layer was extracted with methylene chloride and the combined methylene chloride extracts were Washed with saturated salt solution, dried through sodium sulfate and evaporated. The crude product, amounting to 3.2 g., was chromatographed over g. of neutral alumina using five fractions of 15 0 ml. each of 6% ether-94% Skellysolve B hexanes. The five fractions were combined and evaporated to give 1.145 g. of oily trans-D-1-[2(a,pdimethoxybenzyl cyclohexyl] piperidine.

Ultraviolet: A max. 228 (12,350); 278 (1,550); 284 (1,300).

Analysis.-Calcd. for C H NO (percent): C, 75.67; H, 9.84; N, 4.41. Found (percent): C ,75.48; H, 9.93; N, 4.30.

39 EXAMPLE 95 Trans-C-1-[2-(a,p-dimethoxybenzyl) cyclohexyl] piperidine A solution of 2 g. of hydrogen chloride in 15 ml. of methanol was added to a solution of 0.8 g. (2.64 mmoles) of ap-methoxyphenyl -2-piperidinocyclohexanemethanol (trans-D-isomer) in 40 ml. of methanol. The mixture was allowed to stand overnight. The resulting solution Was basified with 20% aqueous sodium hydroxide solution. The methanol was evaporated in vacuo, 25 ml. of water was added, and the product was extracted with three portions of 25 ml. each of methylene chloride. The extracts were combined, washed with saturated salt solution, dried over magnesium sulfate and evaporated. The residue (0.8 g.) was dissolved in 3% ether-97% Skellysolve B hexanes and chromatographed over neutral alumina with the same solvent mixture. The column was eluted with ten portions of 100 ml. each of 3% ether-97% Skellysolve B hexanes and the fractions thus obtained were evaporated to give 0.351 g. of an oil, which was kept overnight at C. and thereupon solidified. The solidified material was crystallized from methanol to give trans-C-1-[2-(a,pdimethoxybenzyl)cyclohexyl]piperidine of melting point 78-79 C., identical with the compound of Example 93.

EXAMPLE 96 1- [2- a-ethoXy-pmethoxybenzyl) cyclohexyl] piperidine (cis-A isomer) and the hydrochloride thereof A solution of cis-A-a-(p-methoxyphenyl)-2-piperidinocyclohexanemethanol (30.3 g.; 0.1 mole) in 250 m1. of ether was added during 45 minutes to a suspension of freshly prepared sodium amide (0.2 mole) in 1 l. of liquid ammonia. The mixture was stirred for 1 hour and then cooled in a Dry Ice-acetone bath. A solution of 31.2 g. (0.2 mole) of ethyl iodide in 100 ml. of ether was added dropwise over a period of 30 minutes, the mixture was then stirred in the cold for 1 hour and allowed to stir without cooling for 2 hours. The solution was thereupon allowed to evaporate overnight. To the resulting product 500 ml. of water was added, and the mixture was extracted with 5 portions of 100 ml. each of methylene chloride. The extracts were combined, washed with water, then with saturated salt solution, dried by passage through anhydrous sodium sulfate and evaporated to give 30 g. of a yellow oil. A solution of this oil in 200 ml. of petroleum ether (boiling range 3060 C.) was allowed to crystallize overnight to give 15.8 g. (53% recovery) of starting alcohol as determined by mixed melting point (78-80 C.). The filtrate was evaporated, and the residue was chromatographed over 750 g. of neutral alumina. Elution with 6% ether-94% Skellsolve B hexanes (8 fractions of 250 ml. each) gave 7.23 g. of oily cis-A-l- [a-ethoxy-p-methoxyb enzyl) cyclohexyl] piperidine which was 98.9% pure as determined by vapor phase chromatography. Further elution with 25% ether-75% Skellysolve B hexanes (4 fractions of 250 ml. each) gave 0.546 g. of oil of one component; 50% ether-60% Skellysolve B hexanes (4 fractions of 250 ml. each) gave 0.777 g. of oil and 2 fractions of 450 ml. each gave 0.396 g. of oil. Total yield from the ethyl ether fractions was 30%. This oil did not crystallize. The oily cis-A-1-[2-(a-ethoxyp-methoxybenzyl)cyclohexyl1piperidine had the following analysis:

Ultraviolet: Amax. (1,800); 284 (1,550).

Analysis.Calcd. for C H NO (percent): C, 76.09; H, 10.03; N, 4.23. Found (percent): C, 75.97; H, 10.10; N, 4.23.

The hydrochloride of cis-A-1-[2-(ot-ethoxy-p-methoxybenzyl)cyclohexyl1piperidine was prepared by treatment of an ethereal solution of the above oily base with ethereal hydrogen chloride. Two recrystallizations from ethanol gave colorless prisms of the hydrochloride of cis-A-l- [Z-(a ethoxy-p-methoxybenzyl)cyclohexyl]piperidine of melting point 203-2045 C.

40 Ultraviolet: kmax. 227 (11,900); 275 (1,500); 282 (1,300).

Analysis.Calcd. for C H NO -HCl (percent): C, 68.55; H, 9.31; Cl, 9.64; N, 3.81. Found (percent): C, 68.01; H, 9.42; Cl, 9.72; N, 3.59.

EXAMPLE 97 1- 2- a-ethoxy-p-methoxybenzyl cyclohexyl] piperidine cis-B isomer) A solution of 26 g. of hydrogen chloride in 200 ml. of ethanol was added to a solution of cis-A-a-(p-methoxyphenyl)-2-piperidinocyclohexanemethanol (12.1 g.; 0.03 mole) in 1,200 ml. of ethanol. After 20 hours, the mixture was filtered, and a precipitate collected of melting point 232-233 C. This material was unreacted starting material. The filtrate was cooled, basified with 20% sodium hydroxide and evaporated to eliminate the ethanol. Thereafter 250 m1. of water was added to the solution and the solution extracted with methylene chloride to give 11.9 g. of a yellow oil. The yellow oil was dissolved in 50 ml. of methylene chloride and chromatographed on 590 g. of neutral alumina using a solvent mixture of 12% ether-88% Skellysolve B hexanes (6 portions of 250 ml. each). The eluates were combined and evaporated to give 3.80 g. of the cis-B-1-[2-(a-ethoxy-p-methoxybenzyl)cyclohexyl]piperidine as an oil.

Ultraviolet: 227.5 (12,200); 268 (1,100); 276 (1,460); 283 (1,200).

Analysis.Calcd. for C H NO (percent): C, 76.09; H, 10.03; N, 4.23. Found (percent): C, 76.14; H, 9.71; N, 4.31.

EXAMPLE 98 1- 2- a,3 ,4,5-tetramethoxybenzyl cyclohexyl] piperidine (cis-B isomer) A solution of 6 g. of hydrogen chloride in 50 ml. of methanol was added to a solution of cis-A-a-(3,4,5-trimethoxyphenyl)-2-piperidinocyclohexanemethanol hydrochloride (2 g.; 0.005 mole) in 100 ml. of methanol, and the resulting solution was allowed to stand for 24 hours. The colorless solution was then evaporated to dryness at 40 C. The resulting solid was triturated with ether and filtered, to give 2 g. of material melting between 210228 C. This material was crystallized from 20 ml. of methanol to give 0.7 g. of recovered starting material of melting point 257-258 C. The filtrate was diluted with 1 ml. of ether to give 0.35 g. of additional starting material. Further dilution of the filtrate with 50 ml. of ether gave 0.2 g. of starting material; total recovery of staritng material 62.5%. The remaining filtrate was evaporated to dryness to give 0.7 g. of an amorphous solid. A solution of this solid in 20 m1. of water was basified with 20% aqueous sodium hydroxide. The mixture was extracted with three portions of 20 ml. each of methylene chloride. The extracts were combined, washed with water and saturated salt solution, then dried by passage through anhydrous sodium sulfate, and evaporated to give 0.53 g. (26.6% yield) of product. This product was crystallized from methanol to give colorless needles of cis-B-1-[2- (a,3,4,5 tetramethoxybenzyl)cyclohexyl]piperidine of melting point 89-90 C.

Ultraviolet: sh. 235 (7,600); kmax. 271 (868); sh. 280 (675).

Analysis.Calcd. for C H NO (percent): C, 69.99; 'H, 9.35; N, 3.71. Found (percent): C, 70.04; H, 9.47; N, 3.60.

EXAMPLE 99 Cis-A 1 [2 (0:,13 dimethoxybenzyl)cycl0hexyl]hexahydro-lH-azepine and the hydrochloride as methanol solvate A solution of 15.8 ml. of butyl lithium (0.03 mole) in hexane (1.9 M solution) was added dropwise during 5 minutes to a solution of cis-A-a-(p-methoxyphenyl) 2- (hexahydro-lH-azepin-l-yl)cyclohexanemethanol (9.5 g.; 

